DMSO Technical Specifications
Assay by GLC, % Maximum
Water, % by KF, Maximum
Titratable Acid, MEQ/G, Maximum
ACS 8th ed.
ACS 8th ed.
ACS 8th ed.
1. CHEMICAL PRODUCT AND IDENTIFICATION
PRODUCT NAME: Dimethyl Sulfoxide (DMSO) CHEMICAL NAME: Dimethyl Sulfoxide
FORMULA: C2H6OS MOLECULAR WEIGHT: 78.13
- EMERGENCY TRANSPORTATION INFORMATION, CALL:
CHEMTREC (800) 424-9300
2. COMPOSITION/INFORMATION INGREDIENTS
NTP/IARC/OSHA CARCINOGEN: No
3. HAZARDS IDENTIFICATION
WARNING! COMBUSTIBLE LIQUID AND
PHYSICAL APPEARANCE: Clear liquid
ODOR: Essentially odorless
EFFECTS OF OVEREXPOSURE:
|General:||DMSO has shown very few toxic symptoms in humans. The most common are nausea, skin rashes and an unusual garlic-onion-oyster smell on body and breath.|
|Inhalation:||High vapor concentrations may cause headache, dizziness, and sedation.|
|Eyes:||Low hazard for usual industrial handling or commercial handling by trained personnel.|
|Skin:||Stinging and burning of the skin as well as rashes and vesicles have been seen. A heat reaction may occur if applied to wet skin. Avoid contact with DMSO solutions containing toxic material or materials whose toxicological properties are not known since DMSO may penetrate the skin under certain conditions and may carry such materials into the body.|
|Ingestion:||Expected to be a low ingestion hazard.|
HMIS HAZARD RATINGS: Health - 1, Flammability - 1, Chemical Reactivity - 0
NFPA HAZARD RATINGS: Health - 1, Flammability - 1, Chemical Reactivity - 0
Note: HMIS and NFPA ratings involve data and interpretations that may vary from company to company. They are intended only for rapid, general identification of the magnitude of the specific hazard. To deal adequately with the safe handling of this material, all th information contained in this MSDS must be considered.
4. FIRST AID MEASURES
NEVER GIVE FLUIDS OR INDUCE VOMITING IF PATIENT IS UNCONSCIOUS OR IS HAVING CONVULSIONS.
Remove contaminated clothing promptly (launder before reuse).
Flush thoroughly with running water (including under eyelids for at least 15 minutes. If irritation persists after flushing, seek medical attention.
Wash contaminated skin with water. Seek medical attention if irritation persists.
Do not induce vomiting. Seek immediate medical care.
Remove to fresh air. If breathing has stopped, provide artificial respiration. Keep the victim warm and seek medical attention.
5. FIRE-FIGHTING MEASURES
- Combustible liquid and vapor
Flashpoint and method:
89°C (192°F) closed cup
95°C (203°F) open cup
Flammable Limits (% in air):
LEL: 3.0 - 3.5% by volume
UEL: 42 - 63% by volume
300 - 302°C (572 - 575°F)
Foam, carbon dioxide, drypowder, water spray.
Special protective equipment for fire-fighters:
Wear a self contained breathing apparatus.
Special Exposure Hazards:
Burning dimethyl sulfoxide produces poisonous gases (sulfur oxides). Wear gloves, self-contained breathing apparatus, and rubber suit.
Spill, Leak, or Release:
Note: Review sections 3, 4, and 5 of this MSDS before proceedihng with clean up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean up.
6. ACCIDENTAL RELEASE MEASURES
In case of mist formation use a respirator.
If a spill or leak occurs, immediately consult your environmental supervisor. Remove ignition sources. Ventilatethe area. Do not breathe the vapor or get liquid in eyes or on skin/clothing.
Spill Clean-up Methods:
Dilute and flush to wastewater treatment or absorb with inert material. Do not allow the material to enter streams or waterways.
7. HANDLING AND STORAGE
Keep away from sources of ignition. No Smoking. Do not breathe vapor or mist. Avoid contact with skin, eyes, or clothing.
Keep container tightly closed, in a well ventilated place. Freezes (solidifies) at 18.3°C (65°F)
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
ACGIH Threshold Limit Value (TLV): not established
OSHA (USA) Permissible Eposure Limit (PEL, 1989 Table Z-1-A values or section-specific standards): not established
Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. Use process enclosures, local exhaust ventilation, or other engineering controls to maintain ventilation.
In case of mist formation use a respirator. Respirator type: organic vapor. If respirators are used, a program should be instituted to assure compliance with OSHA standard 29 CFR 1910.134
Tightly fitting safety goggles.
Butyl rubber or nitrile (NBR) rubber gloves.
Recommended Decontamination Facilities:
Eye bath, washing facilities
9. PHYSICAL AND CHEMICAL PROPERTIES
|Odor Threshold:||not available|
|Specific Gravity:||1.096 at 20°C (68°F)(water = 1)|
|Vapor Pressure:||0.55 mbar (0.46 mmHg) @ 20°C (68°F)|
|Vapor Density (Air = 1):||2.7|
|Evaporation rate (n-butyl acetate = 1):||0.026|
|Boiling Point:||189°C (372°F)|
|Melting Point:||18.3°C (65°F)|
|Viscosity at 25°C (77°F):||2.0 mPa.s or cP|
|Solubility in water at 20°C:||miscible|
|Octanol/Water Partition Coefficient:||logP = -1.35|
|Sensitivity to Static Discharge:||Material is unlikely to
accumulate a static charge which
could act as an ignition source.
|Flashpoint and method:||89°C (192°F) closed cup|
|95°C (203°F) open cup|
|Flammable Limits (% in air):||LEL: 3.0 - 3.5 % by volume|
|UEL: 42-63 % by volume|
|Autoignition Temperature:||300-302°C (572-575°F)|
10. STABILITY AND REACTIVITY
|Conditions to avoid:||Prolonged heating above 150°C|
|Materials to avoid:||Organic and inorganic acid chlorides, strong oxidizing agents, alkali metals, hydrobromic acid, acidic solutions of alkali bromides|
|Hazardous decomposition products:||Sulfur dioxide, formaldehyde, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and bis (methylthio) methane|
|Hazardous polymerization:||Will not occur|
11. TOXICOLOGICAL INFORMATION
- Data for Dimethyl Sulfoxide:
- Acute Toxicity Data:
Oral LD-50 (male rat):
No mortality rate @ 2,900 mg/m3 (900ppm)/ 24 hrs.
Dermal LD-50 (rat):
Skin irritation (human):
Repeated skin application (human):
Skin sensitization (human):
None by EC protocols
Eye irritation (human):
None by EC protocols
- Subchronic Toxicity Data:**
Oral Study (13 weeks, rat): LOEL = 8800 mg/kg/day (minor target organ effects: liver) ( reduced body weight gain): NOEL = 1100 mg/kg/day
Inhalation study (6 weeks, rat): NOEL = 60ppm
** Note - definitions for data:
LOEL = lowest observed effect level
NOAEL = no observed adverse effect level
NOEL = no observed effect level
- Developmental Toxicity Data:
DMSO bas been studied for adverse effects upon the conceptus in the hamster, mouse, rat, and rabbit by several routes of administration. A definite teratogenic response was obtained in the hamster and mouse after intraperitoneal (i.p.) or subcutaneous (s.c.) administration of DMSO on a single day of gestation at 5.5 g/kg or ore, and in the hamster after a single i.v. administration of 2.5 g/kg. Even a 3.3 g/kg/day dose level may be teratogenic in the hamster if given i.p. for more than one day. Teratogenicity was demonstrated by gavage only in the hamster when given at 11 g/kg on one day of gestation. Gavage is introduction of the material into he stomach via a tube. Teratogenicity was the most sensitive parameter studied in the hamster and in the mouse. In the rat (s.c., i.p., dermal) and the rabbit (s.c., i.v., p.o.) DMSO was not demonstrated to be teratogenic even though the dose levels used (5g/kg) did result in significant embryolethality.
- Mutagenicity/Genotoxicity Data:
Salmonella typhimurium assay (Ames test): negative(+/- activation)
12. ECOLOGICAL INFORMATION
This environmental effects summary is written to assist in addressing emergencies created by an accidental spill which might occur during shipment or handling of this material. It is not meant to address discharges to sanitary sewers or publicly owned treatment works.
- Aquatic Toxicity:
The LC50 (96 hrs.) for ten species of fish range from 32,500 to 43,000 ppm. The LC50 for two species of protozoans are 32,000 and 38,000 ppm. The concentration required to inhibit growth (EC50) for five species f blue-green algae and one green algae species ranged from 0.4 to 4.0%. DMSO -is non-bio-accumulating since the log of the octanol/water partition coefficient is -1.35.
Soaking tomato, cucumber, and bean seeds for 18hrs in up to 8% DMSO solutions had no effect on germination rate. DMSO has no effect on the growth rate of corn when sprayed on at rates up to 30 gallon/acre. When diluted with a large amount of water, release of DMSO, directly of indirectly, to the environment is not expected to have significant effect.
- Biological Oxygen Demand:
Theoretical Oxygen Demand at 10 ppm: 123 mg oxygen Chemical Oxygen Demand at 10 ppm: 107 mg/l Biological Oxygen Demand-5 at 10 ppm: <1.0 mg/l
13. DISPOSAL CONSIDERATIONS
- Disposal Methods
Dilute and flush to an approved wastewater treatment system. Bacterial decomposition of dimethyl sulfoxide during wastewater treatment can result in the release of dimethyl sulfide (a volatile substance with a strong disagreeable odor). Waste DMSO can also be incinerated in an approved furnace where permitted. Consult federal, state or local authorities for proper disposal procedures.
Should be transported/delivered using a registered waste carrier for recycling or waste disposal in accordance with local regulations.
14. TRANSPORT INFORMATION
- DOT (USA) Status:
Bulk (>119 gallons per container)
Proper shipping name: Combustble liquid, N.O.S. (Dimethyl Sulfoxide)
Hazard Class: Combustible liquid
I.D. Number: NA 1993
Packing Group: III
Reportable Quantity: N/A
Quantity limitations: None
Drum (<119 gallons per container)
Proper shipping name: Dimethyl Sulfoxide
Hazard Class: Not regulated
I.D. Number: None
Packing Group: None
TDG (Canada) Status:
ICAO - International Civil Aviation Organization status: unregulated
IATA - International Air Transport Agency status: unregulated
IMDG - International Maritime Dangerous Goods status: unregulated
15. REGULATORY INFORMATION
This document has been prepared in accordance with the MSDS requirements of the OSHA Hazard Communication Standard 29 CFR 1910.1200.
Material(s) known to the State of California to cause cancer: None
Material(s) know to the State of California to cause adverse reproductive effects: None
Massachusetts Substance List: None
New Jersey Workplace Hazardous Substance List: None
Pennsylvania Hazardous Substance List: None
This document has been prepared in accordance with the MSDS requirements of the WHMIS Controlled Products Regulation.
WHMIS (Canada) Ingredient Disclosure List: Listed
WHMIS9 (Canada) Status: Regulated
WHMIS (Canada) Hazard Classification: None
IARC - International Agency for Research on Cancer Carcinogenicity Classification (components present at 0.1% or more): Not Listed
ACGIH - American Conference of Governmental Industrial Hygienists: Not Listed
NTP - National Toxicology Program: Listed
OSHA - Occupational Safety and Health Administration:
Reporting requirements of Section 313 or Title III of the superfund Amendments and Reauthorization Act (SARA) of 1986 and 40 CFR Part 372: None
SARA (U.S.A.) Sections 311 and 312 hazard classification(s): fire hazard
TSCA - US Toxic Substances Control Act: This product is listed on the TSCA inventory.
CEPA/DSL - Canadian Environmental Protection Act/ Domestic Substances List: This product tis listed on the DSL.
EINECS - European Inventory of Existing Commercial chemical Substances: This product is listed on the EINECS.
AICS/NICNAS - Australian Inventory of Chemical Substances/National Industrial Chemical notification and Assessment Scheme: This product is listed on AICS.
Japanese Handbook of Existing and New Chemical Substances: This product is listed in the Handbook.
16. OTHER INFORMATION
COMBUSTIBLE LIQUID AND VAPOR
HIGH VAPOR CONCENTRATIONS MAY CAUSE DROWSINESS
Store away from heat and light.
Distill with caution.
Keep away from heat and flame.
Avoid breathing high vapor concentrations.
Keep container closed.
Use with adequate ventilation.
- FIRST AID:
If inhaled, move to fresh air. Treat symptomatically. Get medical attention of symptoms persist.
- IN CASE OF FIRE:
Eliminate all ignition sources. Flush spill area with water spray. Prevent runoff from entering drains, sewers, and streams.
Since emptied containers retain product residue, follow label warnings even after container is emptied.
FOR MANUFACTURING, PROCESSING OR REPACKING BY TRAINED PERSONNEL
MSDS Issue Date: March 1995
Compiled by: R. L. Willer
Supersedes MSDS Dated: August 1994
The information contained herein is furnished without warranty of any kind. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use and disposal of these material and the safety and health of employees and customers and the protection of the environment. To the best of our knowledge the facts given are correct. However the information is given without warranty as to its accuracy.