Product Description - Amazon Therapeutics Gravi-Agari Herbal Extract Formula 2 fl. oz.
Amazon Therapeutic Labs Gravi-Agari™ is an herbal combination rich in Beta glucans and selective cytotoxic Annonacea acetogenins. This formula is naturally derived from full spectrum Agaricus Sun Supreme™ mushroom Agaricus blazei and the whole leaves of Amazon Graviola Annona muricata. The fruiting body of Agaricus blazei has become Japan's primary immune supporting herb, most frequently recommended for adjunct treatment and support, and Graviola is popular for its use against all types of cancer. Studies show these botanicals are cytotoxic to numerous T-cell lines.1,4,6,7,9,10,11,13,16,17,18,19,20,21,22,24,25,26 Graviola is an effective free radical scavenger, having favorable effects on patients with cancer, augmenting its therapeutic benefits.2,12 It is also antiviral, antibacterial, antifungal, and antiprotozoal (parasites).3,4,5,8 Agaricus is an effective immunomodulator and antimutagenic (cellular protector), having a protective effect against chemically induced DNA damage, and shows natural killer cell activity and improved quality of life with cancer patients undergoing chemotherapy.12,14,15,16,18,19,21,23,25,27.
Suggested Use: Use 10-15 drops mixed with water two to three times daily or as recommended by a practitioner.
Cautions: Contains Graviola which may potentiate antihypertensive and cardiac depressant drugs. Use under care or advice of a medical practitioner. May cause drowsiness. If drowsiness occurs, reduce dosage. Supplementing with probiotics is recommended if used long-term.
Warning: Should not be used during pregnancy. It is not recommended for people with low blood pressure - can have a hypotensive, vasodilator and cardio depressant action. May potentiate antihypertensive and cardiac depressant drugs. People using antihypertensive drugs should monitor blood pressure and adjust medications if necessary. Do not use in combination with MAO inhibitors and some types of prescription antidepressants. Long-term use may disrupt bacteria in the digestive tract. Avoid combining with ATP enhancers like CoQ10.
Ingredients: Graviola (Annona muricata), Agaricus (Agaricus blazei) extracted in distilled water and 40% organic grain alcohol.
More About Gravi-Agari™:
Graviola or Guanabana (Annona muricata)
Annonanceous acetogenins, a novel set of chemicals are derived from the leaf of this popular tropical fruit tree.Numerous studies indicate selective cytotoxicities against several cancer cell lines. Studies point to its reputation and popular use by herbalists. Historical ethnobotanical use is said to be sedative and antispasmodic. Sometimes used to treat, cleanse and support the liver, treat catarrh, and considered anthelmintic, antidiuretic, anti-asthmatic, and sedative.*
Agaricus Sun Supreme™ (Agaricus blazei)
More beta glucans than any of the medicinal mushrooms tested. Shows significant immune stimulating properties. Acts as a tumoricidal, which softens tumors. Has been used for its immune stimulating properties.*
Graviola ~ Annona muricata
- Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae.
Osorio E, Arango GJ, Jimnez N, Alzate F, Ruiz G, Gutirrez D, Paco MA, Gimnez A, Robledo S.
Grupo de Investigacin en Sustancias Bioactivas (GISB), Facultad de Qumica Farmacutica, Corporacin de Patologas Tropicales, Universidad de Antioquia, A.A. 1226, Medelln, Colombia. josorio@farmacia.udeaeduco.
J Ethnopharmacol. 2007 May 22;111(3):630-5. Epub 2007 Jan 18.
PMID: 17296281 [PubMed - indexed for MEDLINE] - In vitro antioxidant studies in leaves of Annona species.
Baskar R, Rajeswari V, Kumar TS.
Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641 006, India. bhubaski@rediffmail.com
Indian J Exp Biol. 2007 May;45(5):480-5.
PMID: 17569293 [PubMed - indexed for MEDLINE] - Antibacterial activity of eight Brazilian annonaceae plants.
Takahashi JA, Pereira CR, Pimenta LP, Boaventura MA, Silva LG.
Departamento de Qumica -- ICEx -- Universidade Federal de Minas Gerais, Av. Antnio Carlos 6627, CEP 31270-901, Belo Horizonte, MG, Brazil. jacfab@dedalus.lcc.ufmg.br
PMID: 16286303 [PubMed - indexed for MEDLINE] - Antitumor and Antiviral Activity of Colombian Medicinal Plant Extracts
LA Betancur-Galvis/+, J Saez*, H Granados*, A Salazar**, JE Ossa
Laboratorio de Virologa, Departamento de Microbiologa y Parasitologa, Facultad de Medicina *Departamento de Qumica **Departamento de Biologa, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Apartado 1226, Medelln, Colombia 531 Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 94(4): 531-535, Jul./Aug. 1999
PMID: 10446015 [PubMed - indexed for MEDLINE] - Isolation and characterization of a lectin from Annona muricata seeds.
Damico DC, Freire MG, Gomes VM, Toyama MH, Marangoni S, Novello JC, Macedo ML.Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas (SP), Brazil.
J Protein Chem. 2003 Nov;22(7-8):655-61.
PMID: 14714732 [PubMed - in process] - New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2002 Apr;65(4):470-5.
PMID: 11975482 [PubMed - indexed for MEDLINE] - Novel cytotoxic annonaceous acetogenins from Annona muricata.
Chang FR, Wu YC.Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2001 Jul;64(7):925-31.
PMID: 11473425 [PubMed - indexed for MEDLINE] - Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus.
Padma P, Pramod NP, Thyagarajan SP, Khosa RL.
Department of Pharmaceutics, IT, Banaras Hindu University, Varanasi, India.
PMID: 9687085 [PubMed - indexed for MEDLINE] - Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.
Wu FE, Zhao GX, Zeng L, Zhang Y, Schwedler JT, McLaughlin JL, Sastrodihardjo S.
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
J Nat Prod. 1995 Sep;58(9):1430-7. - Studies on the chemical constituents of Annona muricata [Article in Chinese]
Yu JG, Gui HQ, Luo XZ, Sun L, Zhu P, Yu ZL.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.
Yao Xue Xue Bao. 1997 Jun;32(6):431-7.
PMID: 11596323 [PubMed - indexed for MEDLINE]
Agaricus Sun Supreme ~ Agaricus blazei
- Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill.
Gao L, Sun Y, Chen C, Xi Y, Wang J, Wang Z.
School of Life Sciences, Lanzhou University.
Braz J Med Biol Res. 2007 Nov;40(11):1545-55. - Measuring Perceived Effects of Drinking an Extract of Basidiomycetes Agaricus blazei Murill: A Survey of Japanese Consumers with Cancer.
Talcott JA, Clark JA, Lee IP.
BMC Complement Altern Med. 2007 Oct 29;7(1):32 [Epub ahead of print]
PMID: 17967191 [PubMed - as supplied by publisher] - Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator.
Murakawa K, Fukunaga K, Tanouchi M, Hosokawa M, Hossain Z, Takahashi K.Division of Marine Biosciences, Graduate School of Fisheries Sciences, Hokkaido University, Hokkaido, Japan.J Oleo Sci. 2007;56(4):179-88. - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.
Lee IP, Kang BH, Roh JK, Kim JR.
Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Republic of Korea.
Food Chem Toxicol. 2008 Jan;46(1):87-95. Epub 2007 Jul 13.
PMID: 17707568 [PubMed - in process] - Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes.
Angeli JP, Ribeiro LR, Gonzaga ML, Soares Sde A, Ricardo MP, Tsuboy MS, Stidl R, Knasmueller S, Linhares RE, Mantovani MS.
Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Cell Biol Toxicol. 2006 Jul;22(4):285-91. Epub 2006 Jun 26.
PMID: 16802105 [PubMed - indexed for MEDLINE - Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice.
Chan Y, Chang T, Chan CH, Yeh YC, Chen CW, Shieh B, Li C.Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
J Microbiol Immunol Infect. 2007 Jun;40(3):201-8.
PMID: 17639159 [PubMed - indexed for MEDLINE] - Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.
Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K.
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Immunology. 2007 Jun;121(2):197-206. Epub 2007 Mar 7.
PMID: 17346284 [PubMed - indexed for MEDLINE] - Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection.
Grinde B, Hetland G, Johnson E.
Division of Infectious Disease Control, Norwegian Institute of Public Health, Ullevl University Hospital, Oslo, Norway. bjorn.grinde@thi.no
Int Immunopharmacol. 2006 Aug;6(8):1311-4. Epub 2006 May 11.
PMID: 16782544 [PubMed - indexed for MEDLINE] - Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy
W.-S. Ahn*1, D.-J. Kim, G.-T. Chae, J.-M. Lee*, S.-M. Bae, J.-I. Sin, Y.-W. Kim, S.-E. Namkoong*& I. P. Lee**Department of Obstetrics and Gynecology; Department of Medical Statistics; Institute of Chronic Disease; and Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
International Journal of Gynecological Cancer 14 (4), 589594.
Volume 14 Issue 4 Page 589 - July 2004
www.blackwell-synergy.com - Activation of antitumor immunity by intratumor injection of biological preparations [Article in Japanese]
Ebina T.
Division of Immunology, Miyagi Cancer Center Research Institute.
Gan To Kagaku Ryoho. 2003 Oct;30(11):1555-8.
PMID: 14619462 [PubMed - indexed for MEDLINE] - Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro.
Martins de Oliveira J, Jordao BQ, Ribeiro LR, Ferreira da Eira A, Mantovani MS.
Departamento de Biologia Geral CCB, Universidade Estadual de Londrina, Campus Universitario, Cx Postal 6001, Londrina, PR, Brazil.
Food Chem Toxicol. 2002 Dec;40(12):1775-80.
PMID: 12419691 [PubMed - indexed for MEDLINE] - Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide.
Delmanto RD, de Lima PL, Sugui MM, da Eira AF, Salvadori DM, Speit G, Ribeiro LR.Departamento de
Patologia, Faculdade de Medicina, UNESP, 18618-000, SP,
Botucatu, Brazil.
Mutat Res. 2001 Sep 20;496(1-2):15-21.
PMID: 11551476 [PubMed - indexed for MEDLINE] - Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill.
Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H.
Graduate School of Science and Technology, Kobe University, Japan.
Biochem Mol Biol Int. 1999 Apr;47(4):707-14.
PMID: 10319424 [PubMed - indexed for MEDLINE] - Antitumor beta glucan from the cultured fruit body of Agaricus blazei.
Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T.
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy & Life Science, Hachioji, Japan. ohnonao@ps.toyaku.ac.jp
Biol Pharm Bull. 2001 Jul;24(7):820-8.
PMID: 11456124 [PubMed - indexed for MEDLINE] - Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice.
Ebina T, Fujimiya Y.
Division of Immunology, Miyagi Cancer Center Research Institute, Natori, Miyagi, Japan.
Biotherapy. 1998;11(4):259-65.
PMID: 9950102 [PubMed - indexed for MEDLINE] - Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action1
Takeshi Takaku*, Yoshiyuki Kimura2 and Hiromichi Okuda
(Journal of Nutrition. 2001;131:1409-1413.) 2001 The American Society for Nutritional Sciences
Second Department of Medical Biochemistry and *Central Research Laboratory, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan
Yao Xue Xue Bao. 1997 Jun;32(6):431-7. - Antimutagenic and bactericidal substances in the fruit body of a Basidiomycete Agaricus blazei, Jun-17 [Article in Japanese]
Osaki Y, Kato T, Yamamoto K, Okubo J, Miyazaki T.
Tokyo College of Pharmacy, Japan.
Yakugaku Zasshi. 1994 May;114(5):342-50.
PMID: 8014843 [PubMed - indexed for MEDLINE]
Graviola ~ Annona muricata
- Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae.
Osorio E, Arango GJ, Jimnez N, Alzate F, Ruiz G, Gutirrez D, Paco MA, Gimnez A, Robledo S.
Grupo de Investigacin en Sustancias Bioactivas (GISB), Facultad de Qumica Farmacutica, Corporacin de Patologas Tropicales, Universidad de Antioquia, A.A. 1226, Medelln, Colombia. josorio@farmacia.udeaeduco.
J Ethnopharmacol. 2007 May 22;111(3):630-5. Epub 2007 Jan 18.
Ethnobotanical and chemotaxonomical studies for antiparasitic activity of Colombian Annonaceae were carried out. In vitro antiprotozoal activity of 36 extracts obtained from six different species was determined against promastigotes of three Leishmania species, epimastigotes of Trypanosoma cruzi and both chloroquine sensitive (F32) and resistant (W2) Plasmodium falciparum. Cytotoxic activity was evaluated in U-937 cells. Active extracts were selected according their selectivity index (SI). Extracts from Annona muricata, Rollinia exsucca, Rollinia pittieri and Xylopia aromatica were active against Leishmania spp. and Trypanosoma cruzi showing IC50 values lower than 25 microg/ml. Hexane extract from Rollinia pittieri leaves was the most selective against Trypanosoma cruzi and Leishmania spp. (IS=10 and 16, respectively). The extracts from Desmopsis panamensis, Pseudomalmea boyacana, Rollinia exsucca and Rollinia pittieri showed good antiplasmodial activity (IC50 < 10 microg/ml). No correlation between antiplasmodial activity and inhibition of beta-hematin production was found. The present study gives specific and useful information about antiprotozoal and cytotoxic activities of some Annonaceae extracts. Results presented here also demonstrate which plants and/or plant parts could be useful in the treatment of leishmaniasis, Chagas disease and malaria.
PMID: 17296281 [PubMed - indexed for MEDLINE] - In vitro antioxidant studies in leaves of Annona species.
Baskar R, Rajeswari V, Kumar TS.
Department of Biotechnology, Kumaraguru College of Technology, Coimbatore 641 006, India. bhubaski@rediffmail.com
Indian J Exp Biol. 2007 May;45(5):480-5.
Antioxidant potential of leaves of three different species of Annona was studied by using different in vitro models eg., 1,1-diphenyl-2-picryl hydrazyl (DPPH), 2,2-azinobis-(3-ethylbenzothizoline-6-sulphonate) (ABTS), nitric oxide, superoxide, hydroxy radical and lipid peroxidation. The ethanolic extract of A. muricata at 500 microg/ml showed maximum scavenging activity (90.05%) of ABTS radical cation followed by the scavenging of hydroxyl radical (85.88%) and nitric oxide (72.60%) at the same concentration. However, the extract showed only moderate lipid peroxidation inhibition activity. In contrast, the extract of A. reticulata showed better activity in quenching DPPH (89.37%) and superoxide radical (80.88%) respectively. A.squamosa extract exhibited least inhibition in all in vitro antioxidant models excepting hydroxyl radical (79.79%). These findings suggest that the extracts of A. muricata possess potent in vitro antioxidant activity as compared to leaves of A. squamosa and A. reticulata suggesting its role as an effective free radical scavenger, augmenting its therapeutic benefits.
PMID: 17569293 [PubMed - indexed for MEDLINE] - Antibacterial activity of eight Brazilian annonaceae plants.
Takahashi JA, Pereira CR, Pimenta LP, Boaventura MA, Silva LG.
Departamento de Qumica -- ICEx -- Universidade Federal de Minas Gerais, Av. Antnio Carlos 6627, CEP 31270-901, Belo Horizonte, MG, Brazil. jacfab@dedalus.lcc.ufmg.br
Nat Prod Res. 2006 Jan;20(1):21-6.
Sixteen extracts, obtained from eight Brazilian plants of Annonaceae family, were screened for their antibacterial activity: Xylopia frutescens, X. aromatica, X. amazonica, X. benthamii, Annona ambotay, A. crassiflora, A. muricata and A. cherimolia. Amongst the investigated extracts, six showed antibacterial activity against at least one of the tested organisms at the concentration of 100 microg/mL. The most active extracts were those prepared from X. frutescens, X. amazonica, and A. ambotay. A phytochemical screening showed the presence of anonaceus acetogenins in some active extracts. Eleven diterpenoids were also tested for comparison purposes. Six were natural products, previously isolated from Xylopia sp. (kaurenoic, frutoic, xylopic, 15beta-hydroxy-kaurenoic and trachylobanic acids plus kaurenol) and five were derivatives of such compounds, obtained by esterification or reduction reactions. Trachylobanic acid showed antibacterial activity against B. subtilis and S. aureus.
PMID: 16286303 [PubMed - indexed for MEDLINE] - Antitumor and Antiviral Activity of Colombian Medicinal Plant Extracts
LA Betancur-Galvis/+, J Saez*, H Granados*, A Salazar**, JE Ossa
Laboratorio de Virologa, Departamento de Microbiologa y Parasitologa, Facultad de Medicina *Departamento de Qumica **Departamento de Biologa, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Apartado 1226, Medelln, Colombia 531 Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 94(4): 531-535, Jul./Aug. 1999
Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type 2 (HSV-2). The 50% cytotoxic concentration (CC50) and the 50% inhibitory concentration of the viral effect (EC50) for each extract were calculated by linear regression analysis. Extracts from Annona muricata, A. cherimolia and Rollinia membranaceal, known for their cytotoxicity were used as positive controls. Likewise, acyclovir and heparin were used as positive controls of antiherpetic activity. Methanolic extract from Annona sp. on HEp-2 cells presented a CC50 value at 72 hr of 49.6x103 g/ml. Neither of the other extracts examined showed a significant cytotoxicity. The aqueous extract from Beta vulgaris, the ethanol extract from Callisia grasilis and the methanol extract Annona sp. showed some antiherpetic activity with acceptable therapeutic indexes (the ratio of CC50 to EC50). These species are good candidates for further activity-monitored fractionation to identify active principles.
PMID: 10446015 [PubMed - indexed for MEDLINE] - Isolation and characterization of a lectin from Annona muricata seeds.
Damico DC, Freire MG, Gomes VM, Toyama MH, Marangoni S, Novello JC, Macedo ML.Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas (SP), Brazil.
J Protein Chem. 2003 Nov;22(7-8):655-61.
A lectin with a high affinity for glucose/mannose was isolated from Annona muricata seeds (Annonaceae) by gel filtration chromatography on Sephacryl S-200, ion exchange chromatography on a DEAE SP-5 PW column, and molecular exclusion on a Protein Pak Glass 300 SW column. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (PAGE) yielded two protein bands of approximately 14 kDa and 22 kDa. However, only one band was seen in native PAGE. The Mr of the lectin estimated by fast-performance liquid chromatography-gel filtration on Superdex 75 was 22 kDa. The lectin was a glycoprotein with 8% carbohydrate (neutral sugar) and required divalent metal cations (Ca2+, Mg2+, and Mn2+) for full activity. Amino acid analysis revealed a large content of Glx, Gly, Phe, and Lys. The lectin agglutinated dog, chicken, horse, goose, and human erythrocytes and inhibited the growth of the fungi Fusarium oxysporum, Fusarium solani, and Colletotrichum musae.
PMID: 14714732 [PubMed - in process] - New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2002 Apr;65(4):470-5.
Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.
PMID: 11975482 [PubMed - indexed for MEDLINE] - Novel cytotoxic annonaceous acetogenins from Annona muricata.
Chang FR, Wu YC.Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2001 Jul;64(7):925-31.
Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five known compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of Annona muricata. The structures of all isolates were elucidated and characterized by spectral and chemical methods. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.
PMID: 11473425 [PubMed - indexed for MEDLINE] - Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus.
Padma P, Pramod NP, Thyagarajan SP, Khosa RL.
Department of Pharmaceutics, IT, Banaras Hindu University, Varanasi, India.
Annona muricata (Annonaceae) and Petunia nyctaginiflora (Solanaceae) were screened for their activity against Herpes simplex virus-1 (HSV-1) and clinical isolate (obtained from the human keratitis lesion). We have looked at the ability of extract(s) to inhibit the cytopathic effect of HSV-1 on vero cells as indicative of anti-HSV-1 potential. The minimum inhibitory concentration of ethanolic extract of A. muricata and aqueous extract of P. nyctaginiflora was found to be 1 mg/ml.
PMID: 9687085 [PubMed - indexed for MEDLINE]
Additional Information
| Manufacturer | Amazon Therapeutics |
|---|---|
| SKU | ATL7688 |
| UPC # | 838451007688 |
| Product Type | Herbal Extract |
| Servings | 60 |
| Days of Use | 30 |
| Country of Manufacture | |
| Herb Extract Base | Alcohol |
| How Many Drops? | 2 fl. oz. = 900 Drops |
| How Many Teaspoons? | 2 fl. oz. = 12 teaspoons |
| How Many Tablespoons? | 2 fl. oz. = 4 Tablespoons |
| Has A Dropper? | Yes |
Amazon TherapeuticsThe HERBS AMERICA COMPANY and MACA MAGIC were founded by Jerome River Black. He was the first to cultivate and distribute live maca root plants in the USA and began germplasm collections and cultivar selection of maca in the Peruvian Altiplano in 1994. In addition to his studies of maca in the Peruvian highlands, Jerome is a published ethnobotanist with a myriad of expertise and an extensive history of working within a variety of botanical experiences. He has explored remote rivers, lakes, and forests in dozens of exotic countries, his travels having taken him to the depths of steamy jungles and the tops of 20 thousand foot mountains... He is the award winner of the Natural Foods Institute "Best New Plants" Award and the subject of numerous articles about plant exploration. He regularly lectures and teaches others about new and rare food-crop development. Jerry currently resides with his family in the lovely rural area of Murphy, Oregon, surrounded by acres of land containing thousands of varieties of rare plants from around the world. Over the course of nearly 20 years, HERBS AMERICA'S founders have used USDA agriculture and agroforestry permits to develop more than 400 rare fruits and new superfoods for introduction into the farming sector and natural foods market. To accomplish this HERBS AMERICA works directly with botanists, tribal leaders, universities, and laboratories to cultivate and research traditional medicines which are found to be beneficial for both humans and the land. Our goal is to bring equitability to small farming operations in developing countries and support indigenous populations in their efforts of preserving culture and the environment while at the same time supporting agrarian economies. Working in more than thirty countries around the world, the company donates and exports fruit trees and vegetable seeds to dozens of farmers in countries on several continents. Our long-term philosophy commits us to our product lines long after they leave the farms and jungles. We like to say: "Eat well! Think well! Live close to nature and work for the good of the community!" We believe that traditional wisdom and modern science can combine important resources for a long-term vision of biological health. We are adamant in our support of indigenous land rights and sustainable agriculture. A portion of our company's annual budget is designated to help protect natural heritage through conservation projects. |
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