DMSO
Technical Specifications
| Specification |
Values |
Methods |
Assay
by GLC, % Maximum
Water, % by
KF, Maximum
Titratable
Acid, MEQ/G, Maximum
Color ALPHA |
99.7
0.10
0.001
10 |
ACS
8th ed.
ACS 8th ed.
ACS 8th ed.
ASTM D-1209-84 |
1. CHEMICAL PRODUCT
AND IDENTIFICATION
PRODUCT NAME: Dimethyl Sulfoxide (DMSO) CHEMICAL NAME: Dimethyl Sulfoxide
MOLECULAR
FORMULA: C2H6OS MOLECULAR WEIGHT: 78.13
- EMERGENCY TRANSPORTATION INFORMATION,
CALL:
CHEMTREC (800) 424-9300
2.
COMPOSITION/INFORMATION INGREDIENTS
Hazardous
Ingredients |
CAS No |
Weight % |
OSHA PEL |
ACGIH TLV |
Dimethyl Sulfoxide |
67-68-5 |
> 99.7 |
Not established |
Not established |
NTP/IARC/OSHA
CARCINOGEN: No
3. HAZARDS
IDENTIFICATION
WARNING! COMBUSTIBLE LIQUID AND
VAPOR
PHYSICAL APPEARANCE: Clear
liquid
ODOR: Essentially odorless
EFFECTS OF OVEREXPOSURE:
| General: |
DMSO has shown very few toxic symptoms in
humans. The most common are nausea, skin rashes and an unusual garlic-onion-oyster smell
on body and breath. |
| Inhalation: |
High vapor concentrations may cause
headache, dizziness, and sedation. |
| Eyes: |
Low hazard for usual industrial handling or
commercial handling by trained personnel. |
| Skin: |
Stinging and burning of the skin as well as
rashes and vesicles have been seen. A heat reaction may occur if applied to wet skin.
Avoid contact with DMSO solutions containing toxic material or materials whose
toxicological properties are not known since DMSO may penetrate the skin under certain
conditions and may carry such materials into the body. |
| Ingestion: |
Expected to be a low ingestion hazard. |
HMIS HAZARD RATINGS: Health - 1, Flammability - 1, Chemical Reactivity - 0
NFPA HAZARD RATINGS: Health - 1, Flammability - 1, Chemical
Reactivity - 0
Note: HMIS and NFPA ratings involve data and
interpretations that may vary from company to company. They are intended only for rapid,
general identification of the magnitude of the specific hazard. To deal adequately with
the safe handling of this material, all th information contained in this MSDS must be
considered.
4. FIRST AID MEASURES
NEVER GIVE FLUIDS OR
INDUCE VOMITING IF PATIENT IS UNCONSCIOUS OR IS HAVING CONVULSIONS.
General advice:
Remove contaminated clothing
promptly (launder before reuse).
Eye Contact:
Flush thoroughly with running
water (including under eyelids for at least 15 minutes. If irritation persists after
flushing, seek medical attention.
Skin Contact:
Wash contaminated skin with
water. Seek medical attention if irritation persists.
Ingestion:
Do not induce vomiting. Seek
immediate medical care.
Inhalation:
Remove to fresh air. If
breathing has stopped, provide artificial respiration. Keep the victim warm and seek
medical attention.
Special advice:
None.
5. FIRE-FIGHTING
MEASURES
- Combustible liquid and vapor
Flashpoint and method:
89°C (192°F) closed cup
95°C (203°F) open cup
Flammable Limits (% in
air):
LEL: 3.0 - 3.5% by volume
UEL: 42 - 63% by volume
Autoignition
Temperature:
300 - 302°C (572 - 575°F)
Extinguishing Media:
Foam, carbon dioxide,
drypowder, water spray.
Special protective
equipment for fire-fighters:
Wear a self contained
breathing apparatus.
Special Exposure
Hazards:
Burning dimethyl sulfoxide
produces poisonous gases (sulfur oxides). Wear gloves, self-contained breathing apparatus,
and rubber suit.
Spill, Leak, or
Release:
Note: Review sections 3,
4, and 5 of this MSDS before proceedihng with clean up. Use appropriate PERSONAL
PROTECTIVE EQUIPMENT during clean up.
6. ACCIDENTAL RELEASE
MEASURES
Personal Precautions:
In case of mist formation use
a respirator.
Environmental
Precautions:
If a spill or leak occurs,
immediately consult your environmental supervisor. Remove ignition sources. Ventilatethe
area. Do not breathe the vapor or get liquid in eyes or on skin/clothing.
Spill Clean-up
Methods:
Dilute and flush to wastewater
treatment or absorb with inert material. Do not allow the material to enter streams or
waterways.
7. HANDLING AND
STORAGE
Usage/Handling
Precautions:
Keep away from sources of
ignition. No Smoking. Do not breathe vapor or mist. Avoid contact with skin, eyes, or
clothing.
Storage Precautions:
Keep container tightly closed,
in a well ventilated place. Freezes (solidifies) at 18.3°C (65°F)
8. EXPOSURE
CONTROLS/PERSONAL PROTECTION
Exposure Limits:
ACGIH Threshold
Limit Value (TLV): not established
OSHA (USA) Permissible Eposure
Limit (PEL, 1989 Table Z-1-A values or section-specific standards): not established
Ventilation:
Good general
ventilation (typically 10 air changes per hour) should be used. Ventilation rates should
be matched to conditions. Use process enclosures, local exhaust ventilation, or other
engineering controls to maintain ventilation.
Respiratory Protection:
In case of mist
formation use a respirator. Respirator type: organic vapor. If respirators are used, a
program should be instituted to assure compliance with OSHA standard 29 CFR 1910.134
Eye Protection:
Tightly fitting
safety goggles.
Skin Protection:
Butyl rubber or
nitrile (NBR) rubber gloves.
Recommended
Decontamination Facilities:
Eye bath, washing
facilities
9. PHYSICAL AND
CHEMICAL PROPERTIES
| Physical Form: |
liquid |
| Color: |
colorless |
| Odor: |
essentially odorless |
| Odor Threshold: |
not available |
| Specific Gravity: |
1.096 at 20°C (68°F)(water =
1) |
| Vapor Pressure: |
0.55 mbar (0.46 mmHg) @ 20°C
(68°F) |
| Vapor Density (Air = 1): |
2.7 |
| Evaporation rate
(n-butyl acetate = 1): |
0.026 |
| Boiling Point: |
189°C (372°F) |
| Melting Point: |
18.3°C (65°F) |
| Viscosity at 25°C (77°F): |
2.0 mPa.s or cP |
| Solubility in water at
20°C: |
miscible |
| Octanol/Water Partition
Coefficient: |
logP = -1.35 |
| Sensitivity
to Static Discharge: |
Material is unlikely to
accumulate a static charge which
could act as an ignition source. |
| Flashpoint and method: |
89°C (192°F) closed cup |
|
95°C (203°F) open cup |
| Flammable Limits (% in
air): |
LEL: 3.0 - 3.5 % by volume |
|
UEL: 42-63 % by volume |
| Autoignition
Temperature: |
300-302°C (572-575°F) |
10. STABILITY AND
REACTIVITY
| Stability: |
Stable |
| Conditions to avoid: |
Prolonged heating above 150°C |
| Materials to avoid: |
Organic and inorganic acid
chlorides, strong oxidizing agents, alkali metals, hydrobromic acid, acidic solutions of
alkali bromides |
| Hazardous decomposition
products: |
Sulfur dioxide, formaldehyde,
methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and bis (methylthio) methane |
| Hazardous
polymerization: |
Will not occur |
11. TOXICOLOGICAL
INFORMATION
- Data for Dimethyl Sulfoxide:
- Acute Toxicity Data:
Oral
LD-50 (male rat): |
14,500-28,300
mg/kg |
Inhalation
(rat): |
No mortality
rate @ 2,900 mg/m3 (900ppm)/ 24 hrs. |
Dermal
LD-50 (rat): |
40,000 mg/kg |
Skin
irritation (human): |
Mild |
Repeated
skin application (human): |
Slight
irritation |
Skin
sensitization (human): |
None by EC
protocols |
Eye
irritation (human): |
None by EC
protocols |
- Subchronic Toxicity Data:**
Oral Study (13
weeks, rat): LOEL =
8800 mg/kg/day (minor target organ effects: liver) ( reduced body weight gain): NOEL =
1100 mg/kg/day
Inhalation study
(6 weeks, rat): NOEL = 60ppm
** Note - definitions
for data:
LOEL = lowest observed effect level
NOAEL = no observed adverse effect level
NOEL = no observed effect level
- Developmental Toxicity Data:
DMSO bas been studied for
adverse effects upon the conceptus in the hamster, mouse, rat, and rabbit by several
routes of administration. A definite teratogenic response was obtained in the hamster and
mouse after intraperitoneal (i.p.) or subcutaneous (s.c.) administration of DMSO on a
single day of gestation at 5.5 g/kg or ore, and in the hamster after a single i.v.
administration of 2.5 g/kg. Even a 3.3 g/kg/day dose level may be teratogenic in the
hamster if given i.p. for more than one day. Teratogenicity was demonstrated by gavage
only in the hamster when given at 11 g/kg on one day of gestation. Gavage is introduction
of the material into he stomach via a tube. Teratogenicity was the most sensitive
parameter studied in the hamster and in the mouse. In the rat (s.c., i.p., dermal) and the
rabbit (s.c., i.v., p.o.) DMSO was not demonstrated to be teratogenic even though the dose
levels used (5g/kg) did result in significant embryolethality.
- Mutagenicity/Genotoxicity Data:
Salmonella typhimurium assay
(Ames test): negative(+/- activation)
12. ECOLOGICAL
INFORMATION
- Introduction:
This environmental effects
summary is written to assist in addressing emergencies created by an accidental spill
which might occur during shipment or handling of this material. It is not meant to address
discharges to sanitary sewers or publicly owned treatment works.
- Aquatic Toxicity:
The LC50 (96 hrs.)
for ten species of fish range from 32,500 to 43,000 ppm. The LC50 for two
species of protozoans are 32,000 and 38,000 ppm. The concentration required to inhibit
growth (EC50) for five species f blue-green algae and one green algae species
ranged from 0.4 to 4.0%. DMSO -is non-bio-accumulating since the log of the octanol/water
partition coefficient is -1.35.
- Phytotoxicity:
Soaking tomato, cucumber, and
bean seeds for 18hrs in up to 8% DMSO solutions had no effect on germination rate. DMSO
has no effect on the growth rate of corn when sprayed on at rates up to 30 gallon/acre.
When diluted with a large amount of water, release of DMSO, directly of indirectly, to the
environment is not expected to have significant effect.
- Biological Oxygen Demand:
| Theoretical Oxygen Demand at 10 ppm: |
123 mg oxygen |
| Chemical Oxygen Demand at 10 ppm: |
107 mg/l |
| Biological Oxygen Demand-5 at 10 ppm: |
<1.0 mg/l |
13. DISPOSAL
CONSIDERATIONS
- Disposal Methods
Waste Disposal:
Dilute and flush to an
approved wastewater treatment system. Bacterial decomposition of dimethyl sulfoxide during
wastewater treatment can result in the release of dimethyl sulfide (a volatile substance
with a strong disagreeable odor). Waste DMSO can also be incinerated in an approved
furnace where permitted. Consult federal, state or local authorities for proper disposal
procedures.
Empty Containers:
Should be
transported/delivered using a registered waste carrier for recycling or waste disposal in
accordance with local regulations.
14. TRANSPORT
INFORMATION
- DOT (USA) Status:
Bulk (>119 gallons
per container)
-
Proper shipping name:
Combustble liquid, N.O.S. (Dimethyl Sulfoxide)
Hazard Class: Combustible liquid
I.D. Number: NA 1993
Packing Group: III
Reportable
Quantity: N/A
Label(s):
None
Quantity
limitations: None
Drum (<119 gallons
per container)
Proper shipping name:
Dimethyl Sulfoxide
Hazard Class:
Not regulated
I.D. Number:
None
Packing Group:
None
TDG (Canada) Status:
unregulated.
ICAO - International Civil Aviation Organization status: unregulated
IATA - International Air Transport Agency status: unregulated
IMDG - International Maritime Dangerous Goods status: unregulated
15. REGULATORY
INFORMATION
This document has been
prepared in accordance with the MSDS requirements of the OSHA Hazard Communication
Standard 29 CFR 1910.1200.
OSHA hazardous
chemical(s): Dimethyl
sulfoxide
Material(s) known to the State of California to cause
cancer: None
Material(s) know to the State of California to cause
adverse reproductive effects: None
Massachusetts Substance List: None
New Jersey Workplace Hazardous Substance List:
None
Pennsylvania Hazardous Substance List: None
This document has been prepared in accordance with the MSDS
requirements of the WHMIS Controlled Products Regulation.
WHMIS (Canada) Ingredient Disclosure List: Listed
WHMIS9 (Canada) Status: Regulated
WHMIS (Canada) Hazard Classification: None
IARC - International Agency for Research on Cancer
Carcinogenicity Classification (components present at 0.1% or more): Not Listed
ACGIH - American Conference of Governmental Industrial
Hygienists: Not Listed
NTP - National Toxicology Program: Listed
OSHA - Occupational Safety and Health Administration:
Reporting requirements of Section 313 or Title III of the superfund Amendments and
Reauthorization Act (SARA) of 1986 and 40 CFR Part 372: None
SARA (U.S.A.) Sections 311 and 312 hazard classification(s):
fire hazard
TSCA - US Toxic Substances Control Act: This product is listed on the TSCA inventory.
CEPA/DSL - Canadian Environmental Protection Act/ Domestic
Substances List: This product tis listed on the DSL.
EINECS - European Inventory of Existing Commercial chemical
Substances: This product is listed on the EINECS.
AICS/NICNAS - Australian Inventory of Chemical
Substances/National Industrial Chemical notification and Assessment Scheme: This product is listed on AICS.
Japanese Handbook of Existing and New Chemical Substances:
This product is listed in the Handbook.
16. OTHER INFORMATION
US/CANADIAN Label
Statements:
WARNING!
COMBUSTIBLE LIQUID AND VAPOR
HIGH VAPOR CONCENTRATIONS MAY CAUSE DROWSINESS
Store away from heat and light.
Distill with caution.
Keep away from heat and flame.
Avoid breathing high vapor concentrations.
Keep container closed.
Use with adequate ventilation.
- FIRST AID:
If inhaled, move to fresh air.
Treat symptomatically. Get medical attention of symptoms persist.
- IN CASE OF FIRE:
Eliminate all ignition
sources. Flush spill area with water spray. Prevent runoff from entering drains, sewers,
and streams.
Since emptied containers
retain product residue, follow label warnings even after container is emptied.
- CAUTION:
FOR
MANUFACTURING, PROCESSING OR REPACKING BY TRAINED PERSONNEL
MSDS Issue Date:
March 1995 |
Compiled by: R. L.
Willer |
Revision No:
Supersedes MSDS Dated: August 1994
The information contained herein is furnished without warranty of
any kind. Users should consider these data only as a supplement to other information
gathered by them and must make independent determinations of suitability and completeness
of information from all sources to assure proper use and disposal of these material and
the safety and health of employees and customers and the protection of the environment. To
the best of our knowledge the facts given are correct. However the information is given
without warranty as to its accuracy.
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