Tranquil Ability™ Mental and Emotional Relief
Tranquil Ability™ — (tonic) —This fast acting blend of botanicals may be used to normalize psychological function.1,2,3,4 It is neuroprotective, with a mild sedative effect on the central nervous system, that helps relieve anxiety, panic disorders, stress, and emotional fatigue.1,2,3,4,5,6,7,8,9,10,20,21,22 It also has antioxidant properties, prevents senility, and has an immunomodulating effect.14,16,17 It is analgesic and anti-inflammatory, which helps with relaxation and the circulation of this tonic.14,15,18,19 Quickly improves physical and mental performance, with mild antidepressant qualities.5,6,7,8,8,10,11,12,13,16,17,20,21,22
Suggested Use: Use 10-15 drops mixed with water two to three times daily or as recommended by a practitioner.
Cautions: Contains Mulungu which may lower blood pressure and may cause drowsiness. Contains Cat’s Claw which may boost immune function and potentiate blood thining medications. May potentiate MOA inhibitors and some anti-depressants. Use under care/advice of a medical practitioner. Not intended for long term therapy .
Contraindications: Do not use before or after an organ or bone marrow transplant.
Ingredients: Mulungu (Erythrina mulungu), Tayuya (Cayaponia tayuya), Wild Lettuce (Lactuca virosa), California Poppy (Eschscholzia californica), Chu Chu Huasi (Maytenus macrocarpa), Astragalus (Astragalus membranaceous), Cat’s Claw (Uncaria tomentosa), Muira Puama (Liriosma ovata). Extracted in distilled water and 40% organic grain alcohol.
More About Tranquil Ability™:
Mulungu 'Erythrina mulungu' | A central nervous system tonic used for anxiety, panic disorders, and as an analgesic. |
Tayuyao'Cayaponia tayuya' | Used to balance and calm nerves, and to relieve emotional fatigue and depression. |
Wild Lettuce 'Lactuca virosa' | Used for its analgesic and sedative properties. Effects are similar to opium, but without the side effects. |
California Poppy 'Eschscholzia californica' | Used to normalize psychological function. It has antispasmodic, sedative and analgesic effects. Relieves nervous tension and anxiety. |
Chu Chu Huasi 'Maytenus macrocarpa' | Used for its analgesic and anti-inflammatory effects. |
Astragalus 'Astragalus membranaceous' | Used for its adaptogenic properties. Studies show improvement of brain dysfunction. |
Cat's Claw 'Uncaria tomentosa' | Used for its anti-inflammatory properties, that help to relax the body, and circulate the blood. |
Muira Puama 'Liriosma ovata' | Used for its anti-anxiety and nervine properties. Increases physical and mental performance. |
Mulungu Erythrina mulungu
1. Effects of chronic treatment with a water-alcohol extract from Erythrina mulungu on anxiety-related responses in rats.
Onusic GM, Nogueira RL, Pereira AM, Flausino Junior OA, Viana Mde B.Laboratory of Psychopharmacology, FFCLRP, University of Sao Paulo, Sao Paulo, Brazil. Biol Pharm Bull. 2003 Nov;26(11):1538-42.
PMID: 14600397 [PubMed - in process]
J Pharm Pharmacol. 2004 Mar;56(3):389-93.
2. Central activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
Vasconcelos SM, Macedo DS, de Melo CT, Paiva Monteiro A, Rodrigues AC, Silveira ER, Cunha GM, Sousa FC,
Viana GS.Department of Physiology and Pharmacology, Federal University of Ceara, Rua Cel. Nunes de Melo 1127,
CEP 60431-270, Fortaleza, Brazil. claussil@bol.com.br
PMID: 15025865 [PubMed - in process]
Braz J Med Biol Res. 2002 Apr;35(4):473-7.
3. Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats.
Onusic GM, Nogueira RL, Pereira AM, Viana MB.Laboratorio de Psicofarmacologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
PMID: 11960198 [PubMed - indexed for MEDLINE]
Biol Pharm Bull. 2003 Jul;26(7):946-9
4. Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
Vasconcelos SM, Reboucas Oliveira G, Mohana de Carvalho M, Rodrigues AC, Rocha Silveira E, Maria Franca Fonteles
M, Florenco Sousa FC, Barros Viana GS.Department of Physiology and Pharmacology, Federal University of Ceara,
Brazil.
PMID: 12843615 [PubMed - indexed for MEDLINE]
Tayuya Cayaponia tayuya
5. Effect of stress and the adaptogen cucurbitacin R diglycoside on arachidonic acid metabolism [Article in Russian]
Panosian AG, Dadaian MA, Gevorkian GA.
PMID: 2497457 [PubMed - indexed for MEDLINE]
6. Prostaglandin E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid levels in the blood of immobilized rats: effect of dihydrocucurbitacin D diglucoside]
[Article in Russian] Dadaian MA, Panosian AG, Karagezian KG, Gevorkian GA.
PMID: 3867195 [PubMed - indexed for MEDLINE]
7. Cucurbitacin R glycoside--a regulator of steroidogenesis and of the formation of prostaglandin E2--a specific modulator of the hypothalamus-hypophysis-adrenal cortex system [Article in Russian]
Panosian AG, Dadaian MA, Gabrielian ES.
PMID: 3479194 [PubMed - indexed for MEDLINE]
Wild Lettuce Lactuca virosa
8. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice.
Wesolowska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-Wojcik E.
Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str., 31-343 Krakow, Poland.
PMID: 16621374 [PubMed - in process]
9. Lettuce, Lactuca spp., as a medicinal plant in polish publications of the 19th century [Article in Polish]
Trojanowska A.
Instytut Historii Nauki PAN Warszawa.
PMID: 17153150 [PubMed - in process]
10. Research on the preparation of lactucin and lactucopicrin from Lactuca virosa plants. 15. On the enzymatic and non-enzymatic oxidation of therapeutically active plant substances. [Article in German]
SCHENCK G, LOTH H, REUBERT W.
PMID: 13747469 [PubMed - indexed for MEDLINE]
California Poppy Eschscholzia californica
11. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.
Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL.
Toms of Maine, 302 Lafayette Center, Kennebunk, Maine 04043, USA. stefang@tomsofmaine.com
PMID: 16562853 [PubMed - indexed for MEDLINE]
12. Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells.
Fujii N, Inui T, Iwasa K, Morishige T, Sato F. Laboratory of Molecular and Cellular Biology of Totipotency, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan, fsato@lif.kyoto-u.ac.jp.
PMID: 17103244 [PubMed - as supplied by publisher
13. Biochemical evidence that berberine bridge enzyme belongs to a novel family of flavoproteins containing a bi-covalently attached FAD cofactor.
Winkler A, Hartner F, Kutchan TM, Glieder A, Macheroux P.
Graz University of Technology, Institute of Biochemistry, Austria.
PMID: 16728404 [PubMed - indexed for MEDLINE]
Chu Chu Huasi Maytenus macrocarpa
14. New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line.
Perez-Victoria JM, Tincusi BM, Jimenez IA, Bazzocchi IL, Gupta MP, Castanys S, Gamarro F, Ravelo AG.
Instituto de Parasitologia y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Cientificas, Ventanilla, 11,18001 Granada, Spain.
PMID: 10543882 [PubMed - indexed for MEDLINE]
15. Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. Achemical study of Maytenus laevis.
Gonzalez JG; delle Monache G; delle Monache F; Marini-Bettol GB
J Ethnopharmacol, 5: 1, 1982 Jan, 73-7
Astragalus Astragalus membranaceous
16. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases [Article in Chinese]
Zhang H, Huang J.
Affiliated Hospital of Guangzhou College of TCM.
PMID: 2397543 [PubMed - indexed for MEDLINE]
17. Studies on pharmacological junctions of hairy root of Astragalus membranaceus
[Article in Chinese]
Jin R, Zhang X, Chen C, Sun Z, Shen Y, Liu D, Hu Z.
Shanghai University of Traditional Chinese Medicine, Shanghai 200032.
PMID: 12205961 [PubMed - indexed for MEDLINE]
Cats Claw Uncaria tomentosa
18. Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.)
DC.Pilarski R, Zielinski H, Ciesiolka D, Gulewicz K.
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego str. 12/14, 61-704 Poznan, Poland.
19. Antiinflammatory actions of cats claw: the role of NF-kappa
B.Sandoval-Chacon M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ.
LSU Medical Center, Department of Paediatrics and Stanley S. Scott Cancer Center, New Orleans, LA 70112, USA.
PMID: 9882039 [PubMed - indexed for MEDLINE]
Muira Puama Liriosma ovata
20. Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice.
da Silva AL, Piato AL, Bardini S, Netto CA, Nunes DS, Elisabetsky E.
Laboratorio de Etnofarmacologia, ICBS, Universidade Federal do Rio Grande do Sul, Av. Sarmento Leite 500/202, 90046-900
Porto Alegre, RS, Brazil.
PMID: 15507336 [PubMed - indexed for MEDLINE]
21. Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices.
Siqueira IR, Cimarosti H, Fochesatto C, Nunes DS, Salbego C, Elisabetsky E, Netto CA.
Departamento de Bioquimica Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. ionara@ufrgs.br
PMID: 15302233 [PubMed - indexed for MEDLINE]
22. Ptychopetalum olacoides, a traditional Amazonian nerve tonic, possesses anticholinesterase activity.
Siqueira IR, Fochesatto C, da Silva AL, Nunes DS, Battastini AM, Netto CA, Elisabetsky E.
Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, RS, 90035-003, Porto Alegre, Brazil.
PMID: 12895682 [PubMed - indexed for MEDLINE]
Mulungu Erythrina mulungu
1. Effects of chronic treatment with a water-alcohol extract from Erythrina mulungu on anxiety-related responses in rats.
Onusic GM, Nogueira RL, Pereira AM, Flausino Junior OA, Viana Mde B.Laboratory of Psychopharmacology, FFCLRP, University of Sao Paulo, Sao Paulo, Brazil. Biol Pharm Bull. 2003 Nov;26(11):1538-42.
We investigated the effects of chronic oral treatment with a water-alcohol extract from the inflorescence of Erythrina mulungu (Leguminosae-Papilionaceae) (EM, 50, 100, 200 mg/kg) in rats submitted to different anxiety models: the elevated T-maze (ETM, for inhibitory avoidance and escape measurements), the light/dark transition, and the cat odor test. These models were selected for their capacity to elicit specific subtypes of anxiety disorders as recognized in clinical practice. Treatment with EM impaired inhibitory avoidance latencies in a way similar to the reference drug, diazepam (DZP). Additionally, both EM and DZP increased the number of transitions and the time spent in the lighted compartment of the light/dark transition model. Furthermore, neither EM nor DZP altered behavioral responses of rats to a cloth impregnated with cat odor. In contrast to DZP, however, EM also altered ETM one-way escape. These results were not due to motor alterations since no significant effects were detected in the number of crossings or rearings in the arena. The present observations suggest that chronic EM exerts anxiolytic-like effects in defensive behaviors related to generalized anxiety and panic disorder. Although alkaloids appear to be one of the main constituents of EM, the possible mechanisms through which the extract exerts its anxiolytic action should be further investigated.
PMID: 14600397 [PubMed - in process]
J Pharm Pharmacol. 2004 Mar;56(3):389-93.
2. Central activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
Vasconcelos SM, Macedo DS, de Melo CT, Paiva Monteiro A, Rodrigues AC, Silveira ER, Cunha GM, Sousa FC,
Viana GS.Department of Physiology and Pharmacology, Federal University of Ceara, Rua Cel. Nunes de Melo 1127,
CEP 60431-270, Fortaleza, Brazil. claussil@bol.com.br
This work studied the central behavioural effects of hydroalcoholic extracts from the stem bark of Erythrina velutina and Erythrina mulungu on the elevated plus maze, open field, and rota rod tests in mice. These medicinal plants belong to the Fabaceae family and are popularly used in Brazil for their effects on the central nervous system. Single doses of the extracts were administered orally (200, 400 or 800 mg kg(-1)) or intraperitoneally (200 or 400 mg kg(-1)) to female mice. A reduction of the locomotor activity was observed in the open field test with both hydroalcoholic extracts after intraperitoneal treatment with all doses, but only with the highest dose after oral administration. In addition, oral and intraperitoneal administration of the extracts decreased the incidence of rearing and grooming. Decreases in the number of entries in the open (NEOA) and closed (NECA) arms of the elevated plus maze were observed after the administration of the highest dose (800 mg kg(-1), p.o.) of both hydroalcoholic extracts, and this effect may be due to the decrease in locomotor activity. These hydroalcoholic extracts failed to affect the motor coordination in the rota rod test. In conclusion, we showed that the hydroalcoholic extracts of E. velutina and E. mulungu have depressant effects on the central nervous system, which, at least partially, corroborates the popular use of these species as tranquilizers in Brazilian popular medicine.
PMID: 15025865 [PubMed - in process]
Braz J Med Biol Res. 2002 Apr;35(4):473-7.
3. Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats.
Onusic GM, Nogueira RL, Pereira AM, Viana MB.Laboratorio de Psicofarmacologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
We investigated the effect of acute oral treatment with a water-alcohol extract of the inflorescence of Erythrina mulungu (EM, Leguminosae-Papilionaceae) (100, 200 and 400 mg/kg) on rats submitted to different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements), the light/dark transition, and the cat odor test. These models were selected for their presumed capacity to demonstrate specific subtypes of anxiety disorders as recognized in clinical practice. Treatment with 200 mg/kg EM impaired avoidance latencies (avoidance 1 - 200 mg/kg EM: 18 +/- 7 s, control group: 40 +/- 9 s; avoidance 2 - 200 mg/kg EM: 15 +/- 4 s, control group: 110.33 +/- 38 s) in a way similar to the reference drug diazepam (avoidance 1: 3 +/- 0.79 s; avoidance 2: 3 +/- 0.76 s), without altering escape. Additionally, the same treatments increased the number of transitions (200 mg/kg EM: 6.33 +/- 0.90, diazepam: 10 +/- 1.54, control group: 2.78 +/- 0.60) between the two compartments and the time spent in the lighted compartment in the light/dark transition model (200 mg/kg EM: 39 +/- 7 s; diazepam: 61 +/- 9 s; control group: 14 +/- 4 s). The dose of 400 mg/kg EM also increased this last measurement (38 +/- 8 s). These results were not due to motor alterations since no significant effects were detected in the number of crossings or rearings in the arena. Furthermore, neither EM nor diazepam altered the behavioral responses of rats to a cloth impregnated with cat odor. These observations suggest that EM exerts anxiolytic-like effects on a specific subset of defensive behaviors, particularly those that have been shown to be sensitive to low doses of benzodiazepines.
PMID: 11960198 [PubMed - indexed for MEDLINE]
Biol Pharm Bull. 2003 Jul;26(7):946-9
4. Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
Vasconcelos SM, Reboucas Oliveira G, Mohana de Carvalho M, Rodrigues AC, Rocha Silveira E, Maria Franca Fonteles
M, Florenco Sousa FC, Barros Viana GS.Department of Physiology and Pharmacology, Federal University of Ceara,
Brazil.
This work studied the antinociceptive effects of the hydroalcoholic extracts (HAEs) from Erythrina velutina (Ev) and Erythrina mulungu (Em) in three experimental models of nociception in mice. The extract was administered intraperitoneally to female mice at the doses of 200 and 400 mg/kg. Inhibitions of abdominal contractions were observed with the doses of 200 (88.6%; 86.8%) and 400 (95.5%; 83.5%) mg/kg of E. velutina and E. mulungu, respectively, as compared to controls. E. velutina and E. mulungu, at both doses, reduced the nociception produced by formalin in the 1st and 2nd phases and this effect was not reversed by the pretreatment with naloxone. In the hot plate test an increase of the reaction time was observed only at 60 (Ev=18.0+/-2.2; Em=20.8+/-2.52) and 90 min (Ev=20.4+/-1.71; Em=23.7+/-2.32) after the treatment with E. velutina and E. mulungu at the dose of 400 mg/kg as compared to controls (T60=11.1+/-0.74; T90=11.9+/-0.86). This effect was not reversed by naloxone. We conclude that E. velutina and E. mulungu presents antinociceptive effects, which are independent of the opioid system.
PMID: 12843615 [PubMed - indexed for MEDLINE]
Tayuya Cayaponia tayuya
5. Effect of stress and the adaptogen cucurbitacin R diglycoside on arachidonic acid metabolism [Article in Russian]
Panosian AG, Dadaian MA, Gevorkian GA.
Rat leukocytic lipoxygenase activity is decreased in stress. The production of 12-hydroxy-5z, 8z, 10E heptadecatrienic acid (12-HHT) (the product of cyclooxygenase metabolism of arachidonic acid-AA) is increased. Cucurbitacin R diglucoside (CRD), an adaptogen, raising working capacity and corticosteroid secretion, produces a similar effect on leukocytes. Preliminary injection of CRD to animals prevents changes caused by stress, which indicates a CRD adaptogenic effect on the body.
PMID: 2497457 [PubMed - indexed for MEDLINE]
6. Prostaglandin E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid levels in the blood of immobilized rats: effect of dihydrocucurbitacin D diglucoside]
[Article in Russian] Dadaian MA, Panosian AG, Karagezian KG, Gevorkian GA.
Content of prostaglandin E2 was decreased more than 6-fold in blood plasma of immobilized rats; on the other hand, concentration of 5-hydroxytetraenoic acid was increased more than 3-fold. No distinct alterations were noted in the prostaglandin F2 alpha content. Intraperitoneal preadministration of 0.1 mg/kg of 2 beta, 25-di (beta-D-glucopyranosyl)-16 alpha; 20-dihydroxy-3, 11, 22-trioxo-cucurbit-5-en into the animals, which as far as is known to augment the working capacity of mice, prevented the stress-induced alterations in the eicosanoid contents in blood plasma.
PMID: 3867195 [PubMed - indexed for MEDLINE]
7. Cucurbitacin R glycoside--a regulator of steroidogenesis and of the formation of prostaglandin E2--a specific modulator of the hypothalamus-hypophysis-adrenal cortex system [Article in Russian]
Panosian AG, Dadaian MA, Gabrielian ES.
2 beta,25-di(0-beta-D-glucopyranosyloxy)-16 alpha,20-dihydroxycucurbit-5-en-3,11,22-trione (cucurbitacin R glucoside--CRG), isolated from Bryonia alba roots, stimulates corticosterone secretion in the adrenal cortex of rats and augments the working capacity of mice. If rats after CRG injections were exposed to immobilization stress, the level of corticosterone in the adrenal cortex and blood plasma was not increased, like in the control groups of rats not receiving CRG. The level of prostaglandin E2 in the adrenal cortex was increased during stress and after CRG administration. These findings indicate that CRG regulates steroidogenesis by influencing the activity of prostaglandin G2-prostaglandin E2 isomerase.
PMID: 3479194 [PubMed - indexed for MEDLINE]
Wild Lettuce Lactuca virosa
8. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice.
Wesolowska A, Nikiforuk A, Michalska K, Kisiel W, Chojnacka-Wojcik E.
Department of New Drugs Research, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Str., 31-343 Krakow, Poland.
Lactucin (1) and its derivatives lactucopicrin (2) and 11beta,13-dihydrolactucin (3), which are characteristic bitter sesquiterpene lactones of Lactuca virosa and Cichorium intybus, were evaluated for analgesic and sedative properties in mice. The compounds showed analgesic effects at doses of 15 and 30 mg/kg in the hot plate test similar to that of ibuprofen, used as a standard drug, at a dose of 30 mg/kg. The analgesic activities of the compounds at a dose of 30 mg/kg in the tail-flick test were comparable to that of ibuprofen given at a dose of 60 mg/kg. Lactucopicrin appeared to be the most potent analgetic of the three tested compounds. Lactucin and lactucopicrin, but not 11beta,13-dihydrolactucin, also showed sedative properties in the spontaneous locomotor activity test.
PMID: 16621374 [PubMed - in process]
9. Lettuce, lactuca sp., as a medicinal plant in polish publications of the 19th century [Article in Polish]
Trojanowska A.
Instytut Historii Nauki PAN Warszawa.
Mentions of lettuce Lactuca sp. that have appeared since antiquity contained similar information on its curative properties, but such properties were ascribed to different species or varieties. Apart from the wild and poisonous lettuce, also garden or common lettuce were identified as having curative action, and some publications lacked information enabling the precise identification of the lettuce in question. In the 19th century, attempts were made to put some order into the knowledge of lettuce as a medicinal plant. Information contained in Polish medical studies of the 19th century on lettuce points to the poisonous species, Lactuca virosa, and the common or garden lettuce, Lactuca sativa v. Lactuca hortensis, as being used as a medicinal plant. In that period, lettuce and especially the the desiccated lactescent juice obtained from it, lactucarium, were considered to be an intoxicant, and were used as a sedative and an analgesic. The action of the substance was weaker than that of opium but free of the side-effects, and medical practice showed that in some cases lactucarium produced better curative effects than opium. To corroborate those properties of lettuce and its lactescent juice, studies were undertaken to find the substance responsible for the curative effects of the juice. However, such studies failed to produce the expected results, and the component responsible for the curative properties of letuce was not identified. Medical practice thus had to restrict itself to the uses of the desiccated lactescent juice and extracts obtained from it. The possibility of obtaining lactucarium from plants cultivated in Poland caused Polish pharmacists and physicians to take an interest in the stuff and launch their own research of lettuce and the lactescent juice obtained from it. Results of research on lettuce were published in 19th-century journals by, among others, Jan Fryderyk Wolfgang, Florian Sawiczewski and Jozef Orkisz.
PMID: 17153150 [PubMed - in process]
10. Research on the preparation of lactucin and lactucopicrin from Lactuca virosa plants. 15. On the enzymatic and non-enzymatic oxidation of therapeutically active plant substances. [Article in German]
SCHENCK G, LOTH H, REUBERT W.
PMID: 13747469 [PubMed - indexed for MEDLINE]
California Poppy Eschscholzia californica