Product Description - Amazon Therapeutics Graviola Wildcrafted Herbal Extract 2 fl. oz.
Graviola Annona muricata (Annonaceae)
Liquid extracts cited in the numerous studies indicated selective cytotoxicities against several cancer cell lines*. The phytochemicals are derived from the leaf of this popular tropical fruit tree. Studies below point to its reputation and popular use by herbalists. Historical ethnobotanical use is said to be sedative and anti-spasmodic. Sometimes used to treat, cleanse and support the liver, treat catarrh, and considered anthelmintic, antidiuretic, anti-asthmatic and digestive. (References below).
Suggested Use: Use 15-20 drops mixed with water two to three times daily, or more as recommended by a practitioner.
Cautions: Use under care or advice of a medical practitioner. Not intended for long term therapy.
Contraindications: Should not be used during pregnancy. It is not recommended for people with low blood pressure, can have a hypotensive, vasodilator and cardio depressant action. May potentiate antihypertensive and cardiac depressant drugs. It may potentiate antidepressant drugs. People using antihypertensive drugs should monitor blood pressure and adjust medications if necessary. Do not use in combination with MAO inhibitors and some types of prescription antidepressants. Long-term use may disrupt bacteria in the digestive tract. Can promote drowsiness. Reduce the amount used if feeling tired.
Ingredients: 100% Graviola leaf extracted in distilled water and 40% organic grain alcohol.
More About Graviola:
1. Novel cytotoxic annonaceous acetogenins from Annona muricata.
Chang FR, Wu YC.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five known compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of Annona muricata. The structures of all isolates were elucidated and characterized by spectral and chemical methods. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.
J Nat Prod. 2001 Jul;64(7):925-31.
PMID: 11473425 [PubMed - indexed for MEDLINE]
2. Isolation and characterization of a lectin from Annona muricata seeds.
Damico DC, Freire MG, Gomes VM, Toyama MH, Marangoni S, Novello JC, Macedo ML.
Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas (SP), Brazil.
A lectin with a high affinity for glucose/mannose was isolated from Annona muricata seeds (Annonaceae) by gel filtration chromatography on Sephacryl S-200, ion exchange chromatography on a DEAE SP-5 PW column, and molecular exclusion on a Protein Pak Glass 300 SW column. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (PAGE) yielded two protein bands of approximately 14 kDa and 22 kDa. However, only one band was seen in native PAGE. The Mr of the lectin estimated by fast-performance liquid chromatography-gel filtration on Superdex 75 was 22 kDa. The lectin was a glycoprotein with 8% carbohydrate (neutral sugar) and required divalent metal cations (Ca2+, Mg2+, and Mn2+) for full activity. Amino acid analysis revealed a large content of Glx, Gly, Phe, and Lys. The lectin agglutinated dog, chicken, horse, goose, and human erythrocytes and inhibited the growth of the fungi Fusarium oxysporum, Fusarium solani, and Colletotrichum musae.
J Protein Chem. 2003 Nov;22(7-8):655-61.
PMID: 14714732 [PubMed - in process]
3. [Studies on the chemical constituents of Annona muricata] [Article in Chinese]
Yu JG, Gui HQ, Luo XZ, Sun L, Zhu P, Yu ZL.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.
Yao Xue Xue Bao. 1997 Jun;32(6):431-7.
Annonaceous acetogenin (or polyketide) is a kind of potential antineoplastic agents from Annonaceae plants. Two new acetogenins, Muricatalicin (I) and muricatalin (VI), a mesitoate of a new acetogenin, annonacin-B mesitoate (Vb), and three known acetogenins, annonacin (II), annonacin-A (III) and annonacin-10-one (IV) have been isolated from Annona muricata L. The structures and relative stereochemistry of I, VI and Vb were elucidated on the basis of spectral analysis and examination of their acetates and/or mesitoate.
PMID: 11596323 [PubMed - indexed for MEDLINE]
4. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus.
Padma P, Pramod NP, Thyagarajan SP, Khosa RL.
Department of Pharmaceutics, IT, Banaras Hindu University, Varanasi, India.
Annona muricata (Annonaceae) and Petunia nyctaginiflora (Solanaceae) were screened for their activity against Herpes simplex virus-1 (HSV-1) and clinical isolate (obtained from the human keratitis lesion). We have looked at the ability of extract(s) to inhibit the cytopathic effect of HSV-1 on vero cells as indicative of anti-HSV-1 potential. The minimum inhibitory concentration of ethanolic extract of A. muricata and aqueous extract of P. nyctaginiflora was found to be 1 mg/ml.
J Ethnopharmacol. 1998 May;61(1):81-3.
PMID: 9687085 [PubMed - indexed for MEDLINE]
5. New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata.
Liaw CC, Chang FR, Lin CY, Chou CJ, Chiu HF, Wu MJ, Wu YC.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.
J Nat Prod. 2002 Apr;65(4):470-5.
6. Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.
Wu FE, Zhao GX, Zeng L, Zhang Y, Schwedler JT, McLaughlin JL, Sastrodihardjo S.
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
In a continuation of our research on bioactive components from the leaves of Annona muricata, three novel monotetrahydrofuran Annonaceous acetogenins, namely, annomutacin , (2,4-trans)-10R-annonacin-A-one , and (2,4-cis)-10R- annonacin-A-one , have been identified. Their structures were deduced by ms, nmr, ir, and uv spectral and chemical methods, and the absolute configurations were determined by Mosher ester methodology. A known bioactive amide, N-p-coumaroyl tyramine, was also found. Compound 1 and the mixture of compounds 2 and 3 showed selective cytotoxicities against the human A-549 lung tumor cell line.
J Nat Prod. 1995 Sep;58(9):1430-7.
|Product Type||Herbal Extract|
|Days of Use||30|
|Country of Manufacture|
|How Many Drops?||2 fl. oz. = 900 Drops|
|How Many Teaspoons?||2 fl. oz. = 12 teaspoons|
|How Many Tablespoons?||2 fl. oz. = 4 Tablespoons|
The HERBS AMERICA COMPANY and MACA MAGIC were founded by Jerome River Black. He was the first to cultivate and distribute live maca root plants in the USA and began germplasm collections and cultivar selection of maca in the Peruvian Altiplano in 1994. In addition to his studies of maca in the Peruvian highlands, Jerome is a published ethnobotanist with a myriad of expertise and an extensive history of working within a variety of botanical experiences. He has explored remote rivers, lakes, and forests in dozens of exotic countries, his travels having taken him to the depths of steamy jungles and the tops of 20 thousand foot mountains...
He is the award winner of the Natural Foods Institute "Best New Plants" Award and the subject of numerous articles about plant exploration. He regularly lectures and teaches others about new and rare food-crop development. Jerry currently resides with his family in the lovely rural area of Murphy, Oregon, surrounded by acres of land containing thousands of varieties of rare plants from around the world.
Over the course of nearly 20 years, HERBS AMERICA'S founders have used USDA agriculture and agroforestry permits to develop more than 400 rare fruits and new superfoods for introduction into the farming sector and natural foods market. To accomplish this HERBS AMERICA works directly with botanists, tribal leaders, universities, and laboratories to cultivate and research traditional medicines which are found to be beneficial for both humans and the land. Our goal is to bring equitability to small farming operations in developing countries and support indigenous populations in their efforts of preserving culture and the environment while at the same time supporting agrarian economies. Working in more than thirty countries around the world, the company donates and exports fruit trees and vegetable seeds to dozens of farmers in countries on several continents.
Our long-term philosophy commits us to our product lines long after they leave the farms and jungles. We like to say: "Eat well! Think well! Live close to nature and work for the good of the community!" We believe that traditional wisdom and modern science can combine important resources for a long-term vision of biological health. We are adamant in our support of indigenous land rights and sustainable agriculture. A portion of our company's annual budget is designated to help protect natural heritage through conservation projects.
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