Amazon Therapeutic Labs Cat's Claw Una de Gato Bark Wildcrafted Bulk Herb 1 lb.

Item #: HA-UNADEGATOLB

$76.99

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Famous anti-inflammatory for arthritis, diabetes, and inflammatory disorder relief
Organic No Animal Testing Non Irradiated. No Irradiation. Vegetarian

Product Description - Amazon Therapeutic Labs Cat's Claw Una de Gato Bark Wildcrafted Bulk Herb 1 lb.

Hoxsey Red Clover Burdock Plus Blood Cleansing Herbal Formula

Una de Gato aka Cat's Claw Uncaria tomentosa

A sixty-foot jungle vine found throughout South America, Cats Claw, named for the curved spines found on young branches, is used in the Peruvian Amazon to treat arthritis, diabetes, and inflammatory disorders3. Recently, Ua de Gato has become popular around the world in the treatment of cancer and immune system related diseases1, 2. Renowned anti-inflammatory, our liquid extracts can be felt in five minutes.

Suggested UseLiquids:Use 10-15 drops mixed with water two to three times daily or as recommended by a practitioner.
TeaOne tsp loose leaf per 16 oz of boiling water.

Suggested UseTea:One tsp loose leaf per 16 oz of boiling water.

Suggested UseCapsules:One tsp loose leaf per 16 oz of boiling water.

Cautions:May thin blood. Large doses (3-4g) may cause diarrhea. Discontinue use or reduce dosage if diarrhea persists longer than three or four days.

Contraindications: Check with your doctor if you are taking coumadin or any other blood-thinning drugs.

Ingredients:Extracted in distilled water and 40% organic grain alcohol.

 

More About Una de Gato
aka Cat's Claw

Uncaria tomentosa, also known as cats claw, an herb from the highlands of the Peruvian Amazon, has been used by natives for hundreds of years to treat immunologic and digestive disorders. Research began in the 1970s to discover the benefits of this plant in relieving symptoms of cancers, arthritis, and other ailments. It has the ability to cleanse the digestive tract, aiding victims of Crohns, colitis, gastritis and more. In a 1989 study by Klaus Keplinger, several alkaloid oxidants found in the plants roots showed an ability to stimulate the immune system. The principal alkaloids are isopteropodine and rynchophyiline. Extracts of cats claw mixed with AZT in an experimental drug, called Krallendom, were effective in reducing symptoms in AIDS patients in Austria. The plant has been useful in reducing secondary effects of radiation and chemotherapy in cancer victims as well.
Steinberg PN
Sidahora. 1995 Apr-May;:35-6.

1. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F.
Section for Immunology, Department of Cell and Molecular Biology, BMC I:13, Lund University, Lund, SE-221 84, Sweden.
Int Immunopharmacol. 2003 Dec;3(13-14):1889-900.
PMID14636838 [PubMed - in process]

2. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.
Sheng Y, Pero RW, Amiri A, Bryngelsson C.
Department of Cell and Molecular Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Anticancer Res. 1998 Sep-Oct;18(5A):3363-8
PMID9858909 [PubMed - indexed for MEDLINE]

3. Antiinflammatory actions of cats clawthe role of NF-kappaB.
Sandoval-Chacon M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ.
LSU Medical Center, Department of Paediatrics and Stanley S. Scott Cancer Center, New Orleans, LA 70112, USA.
Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89.
PMID9882039 [PubMed - indexed for MEDLINE]

4. Cats claw inhibits TNFalpha production and scavenges free radicalsrole in cytoprotection.
Sandoval M, Charbonnet RM, Okuhama NN, Roberts J, Krenova Z, Trentacosti AM, Miller MJ.
Department of Pediatrics and Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA. sandovm@mail.amc.edu
Free Radic Biol Med. 2000 Jul 1;29(1):71-8
PMID10962207 [PubMed - indexed for MEDLINE]

5. Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis.
Miller MJ, Angeles FM, Reuter BK, Bobrowski P, Sandoval M.
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. millermj@mail.amc.edu
BMC Complement Altern Med. 2001;1(1):11. Epub 2001 Dec 10
PMID11749672 [PubMed - indexed for MEDLINE]

6. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study.
Sheng Y, Li L, Holmgren K, Pero RW.
Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Phytomedicine. 2001 Jul;8(4):275-82
PMID11515717 [PubMed - indexed for MEDLINE]

7. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in miceelucidation using the passive avoidance test.
Mohamed AF, Matsumoto K, Tabata K, Takayama H, Kitajima M, Watanabe H.
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
PMID11197086 [PubMed - indexed for MEDLINE]

8. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Sheng Y, Bryngelsson C, Pero RW.
Department of Cell and Molecular Biology, University of Lund, Sweden. yezhou.sheng@wblab.lu.se
J Ethnopharmacol. 2000 Feb;69(2):115-26.
PMID10687868 [PubMed - indexed for MEDLINE]

9. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
Sheng Y, Pero RW, Wagner H.
Department of Cell and Molecular Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Phytomedicine. 2000 Apr;7(2):137-43.
PMID10839217 [PubMed - indexed for MEDLINE]

10. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100.
Lamm S, Sheng Y, Pero RW.
Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden.
Phytomedicine. 2001 Jul;8(4):267-74
PMID11515716 [PubMed - indexed for MEDLINE]

11. In vitro Effects of Two Extracts and Two Pure Alkaloid Preparations of Uncaria tomentosa on Peripheral Blood Mononuclear Cells.
Winkler C, Wirleitner B, Schroecksnadel K, Schennach H, Mur E, Fuchs D.
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria.
Planta Med. 2004 Mar;70(3):205-10.
PMID15114496 [PubMed - in process]

1. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death.
Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F.
Section for Immunology, Department of Cell and Molecular Biology, BMC I:13, Lund University, Lund, SE-221 84, Sweden.
Int Immunopharmacol. 2003 Dec;3(13-14):1889-900.
Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100 inhibits nuclear factor kappa B (NF-kappa B) activity and propose that this at least partially causes the inhibition of proliferation.
PMID14636838 [PubMed - in process]

2. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.
Sheng Y, Pero RW, Amiri A, Bryngelsson C.
Department of Cell and Molecular Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Anticancer Res. 1998 Sep-Oct;18(5A):3363-8
Growth inhibitory activities of novel water extracts of Uncaria tomentosa (C-Med-100) were examined in vitro using two human leukemic cell lines (K562 and HL60) and one human EBV-transformed B lymphoma cell line (Raji). The proliferative capacities of HL60 and Raji cells were strongly suppressed in the presence of the C-Med-100 while K562 was more resistant to the inhibition. Furthermore, the antiproliferative effect was confirmed using the clonogenic assay, which showed a very close correlation between C-Med-100 concentration and the surviving fraction. The suppressive effect of Uncaria tomentosa extracts on tumor cell growth appears to be mediated through induction of apoptosis which was demonstrated by characteristic morphological changes, internucleosomal DNA fragmentation after agarose gel electrophoresis and DNA fragmentation quantification. C-Med-100 induced a delayed type of apoptosis becoming most dose-dependently prominent after 48 hours of exposure. Both DNA single and double strand breaks were increased 24 hours after C-Med-100 treatment, which suggested a well-established linkage between the DNA damage and apoptosis. The induction of DNA strand breaks coupled to apoptosis may explain the growth inhibition of the tumor cells by Uncaria tomentosa extracts. These results provide the first direct evidence for the antitumor properties of Uncaria tomentosa extracts to be via a mechanism of selective induction of apoptosis.
PMID9858909 [PubMed - indexed for MEDLINE]

3. Antiinflammatory actions of cats clawthe role of NF-kappaB.
Sandoval-Chacon M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ.
LSU Medical Center, Department of Paediatrics and Stanley S. Scott Cancer Center, New Orleans, LA 70112, USA.
Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89.
BACKGROUNDUncaria tomentosa is a vine commonly known as cats claw or una de gato (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularly digestive complaints and arthritis. PURPOSEThe aim of this study was to determine the proposed anti-inflammatory properties of cats claw. Specifically(i) does a bark extract of cats claw protect against oxidant-induced stress in vitro, and (ii) to determine if UG modifies transcriptionally regulated events. METHODSCell death was determined in two cell lines, RAW 264.7 and HT29 in response to peroxynitrite (PN, 300 microM). Gene expression of inducible nitric oxide synthase (iNOS) in HT29 cells, direct effects on nitric oxide and peroxynitrite levels, and activation of NF-kappaB in RAW 264.7 cells as influenced by UG were assessed. Chronic intestinal inflammation was induced in rats with indomethacin (7.5 mg/kg), with UG administered orally in the drinking water (5 mg/mL). RESULTSThe administration of UG (100 microg/mL) attenuated (P < 0.05) peroxynitrite-induced apoptosis in HT29 (epithelial) and RAW 264.7 cells (macrophage). Cats claw inhibited lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB. Cats claw markedly attenuated indomethacin-enteritis as evident by reduced myeloperoxidase activity, morphometric damage and liver metallothionein expression. CONCLUSIONSCats claw protects cells against oxidative stress and negated the activation of NF-kappaB. These studies provide a mechanistic evidence for the widely held belief that cats claw is an effective anti-inflammatory agent.
PMID9882039 [PubMed - indexed for MEDLINE]

4. Cats claw inhibits TNFalpha production and scavenges free radicalsrole in cytoprotection.
Sandoval M, Charbonnet RM, Okuhama NN, Roberts J, Krenova Z, Trentacosti AM, Miller MJ.
Department of Pediatrics and Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA. sandovm@mail.amc.edu
Free Radic Biol Med. 2000 Jul 1;29(1):71-8
Cats claw (Uncaria tomentosa) is a medicinal plant from the Amazon River basin that is widely used for inflammatory disorders and was previously described as an inhibitor of NF-kappaB. Cats claw was prepared as a decoction (water extraction) of micropulverized bark with and without concentration by freeze-drying. Murine macrophages (RAW 264.7 cells) were used in cytotoxicity assays (trypan blue exclusion) in response to the free radical 1, 1-diphenyl-2-picrilhydrazyl (DPPH, 0.3 microM) and ultraviolet light (UV) light. TNFalpha production was induced by lipopolysaccharide (LPS 0.5 microg/ml). Cats claw was an effective scavenger of DPPH; the EC(50) value for freeze-dried concentrates was significantly less than micropulverized (18 vs. 150 microg/ml, p <.05). Cats claw (10 microg/ml freeze-dried) was fully protective against DPPH and UV irradiation-induced cytotoxicity. LPS increased TNFalpha media levels from 3 to 97 ng/ml. Cats claw suppressed TNFalpha production by approximately 65-85% (p <.01) but at concentrations considerably lower than its antioxidant activityfreeze-dried EC(50) = 1.2 ng/ml, micropulverized EC(50) = 28 ng/ml. In conclusion, cats claw is an effective antioxidant, but perhaps more importantly a remarkably potent inhibitor of TNFalpha production. The primary mechanism for cats claw anti-inflammatory actions appears to be immunomodulation via suppression of TNFalpha synthesis.
PMID10962207 [PubMed - indexed for MEDLINE]

5. Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis.
Miller MJ, Angeles FM, Reuter BK, Bobrowski P, Sandoval M.
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA. millermj@mail.amc.edu
BMC Complement Altern Med. 2001;1(1):11. Epub 2001 Dec 10
BACKGROUNDThe potential of ascorbic acid and two botanical decoctions, green tea and cats claw, to limit cell death in response to oxidants were evaluated in vitro. METHODSCultured human gastric epithelial cells (AGS) or murine small intestinal epithelial cells (IEC-18) were exposed to oxidants - DPPH (3 microM), H2O2 (50 microM), peroxynitrite (300 microM) - followed by incubation for 24 hours, with antioxidants (10 microg/ml) administered as a 1 hour pretreatment. Cell number (MTT assay) and death via apoptosis or necrosis (ELISA, LDH release) was determined. The direct interactions between antioxidants and DPPH (100 microM) or H2O2 (50 microM) were evaluated by spectroscopy. RESULTSThe decoctions did not interact with H2O2, but quenched DPPH although less effectively than vitamin C. In contrast, vitamin C was significantly less effective in protecting human gastric epithelial cells (AGS) from apoptosis induced by DPPH, peroxynitrite and H2O2 (P < 0.001). Green tea and cats claw were equally protective against peroxynitrite and H2O2, but green tea was more effective than cats claw in reducing DPPH-induced apoptosis (P < 0.01). Necrotic cell death was marginally evident at these low concentrations of peroxynitrite and H2O2, and was attenuated both by cats claw and green tea (P < 0.01). In IEC-18 cells, all antioxidants were equally effective as anti-apoptotic agents. CONCLUSIONSThese results indicate that dietary antioxidants can limit epithelial cell death in response to oxidant stress. In the case of green tea and cats claw, the cytoprotective response exceed their inherent ability to interact with the injurious oxidant, suggestive of actions on intracellular pathways regulating cell death.
PMID11749672 [PubMed - indexed for MEDLINE]

6. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study.
Sheng Y, Li L, Holmgren K, Pero RW.
Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Phytomedicine. 2001 Jul;8(4):275-82
The Uncaria tomentosa water extracts (C-Med-100) have been shown to enhance DNA repair, mitogenic response and leukocyte recovery after chemotherapy-induced DNA damage in vivo. In this study, the effect of C-Med-100 supplement was evaluated in a human volunteer study. Twelve apparently healthy adults working in the same environment were randomly assigned into 3 groups with age and gender matched. One group was daily supplemented with a 250 mg tablet containing an aqueous extract of Uncaria tomentosa of C-Med-100, and another group with a 350 mg tablet, for 8 consecutive weeks. DNA repair after induction of DNA damage by a standard dose of hydrogen peroxide was measured 3 times before supplement and 3 times after the supplement for the last 3 weeks of the 8 week-supplement period. There were no drug-related toxic responses to C-Med-100 supplement when judged in terms of clinical symptoms, serum clinical chemistry, whole blood analysis and leukocyte differential counts. There was a statistically significant decrease of DNA damage and a concomitant increase of DNA repair in the supplement groups (250 and 350 mg/day) when compared with non-supplemented controls (p < 0.05). There was also an increased tendency of PHA induced lymphocyte proliferation in the treatment groups. Taken together, this trial has confirmed the earlier results obtained in the rat model when estimating DNA repair enhancement by C-Med-100.
Publication TypesClinical Trial Randomized Controlled Trial
PMID11515717 [PubMed - indexed for MEDLINE]

7. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in miceelucidation using the passive avoidance test.
Mohamed AF, Matsumoto K, Tabata K, Takayama H, Kitajima M, Watanabe H.
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
The effects of Uncaria tomentosa total alkaloid and its oxindole alkaloid components, uncarine E, uncarine C, mitraphylline, rhynchophylline and isorhynchophylline, on the impairment of retention performance caused by amnesic drugs were investigated using a step-down-type passive avoidance test in mice. In this test, the retention performance of animals treated with the amnesic and test drugs before training was assessed 24 h after training. Uncaria tomentosa total alkaloid (10-20 mg kg(-1), i.p.) and the alkaloid components (10-40 mg kg(-1), i.p.), as well as the muscarinic receptor agonist oxotremorine (0.01 mg kg(-1), i.p.), significantly attenuated the deficit in retention performance induced by the muscarinic receptor antagonist scopolamine (3 mg kg(-1), i.p.). The effective doses of uncarine C and mitraphylline were larger than those of other alkaloid components. Uncarine E (20 mg kg(-1), i.p.) also blocked the impairment of passive avoidance performance caused by the nicotinic receptor antagonist mecamylamine (15 mg kg(-1), i.p.) and the N-methyl-D-aspartate (NMDA) receptor antagonist (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP; 7.5 mg kg(-1), i.p.), but it failed to affect the deficit caused by the benzodiazepine receptor agonist diazepam (2 mg kg(-1), i.p.). Rhynchophylline significantly reduced the mecamylamine-induced deficit in passive avoidance behaviour, but it failed to attenuate the effects of CPP and diazepam. These results suggest that Uncaria tomentosa total alkaloids exert a beneficial effect on memory impairment induced by the dysfunction of cholinergic systems in the brain and that the effect of the total alkaloids is partly attributed to the oxindole alkaloids tested. Moreover, these findings raised the possibility that the glutamatergic systems are implicated in the anti-amnesic effect of uncarine E.
PMID11197086 [PubMed - indexed for MEDLINE]

8. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Sheng Y, Bryngelsson C, Pero RW.
Department of Cell and Molecular Biology, University of Lund, Sweden. yezhou.sheng@wblab.lu.se
J Ethnopharmacol. 2000 Feb;69(2):115-26.
Female W/Fu rats were gavaged daily with a water-soluble extract (C-MED-100) of Uncaria tomentosa supplied commercially by CampaMed at the doses of 0, 5, 10, 20, 40 and 80 mg/kg for 8 consecutive weeks. Phytohemagglutinin (PHA) stimulated lymphocyte proliferation was significantly increased in splenocytes of rats treated at the doses of 40 and 80 mg/kg. White blood cells (WBC) from the C-MED-100 treatment groups of 40 and 80 mg/kg for 8 weeks or 160 mg/kg for 4 weeks were significantly elevated compared with controls (P < 0.05). In a human volunteer study, C-MED-100 was given daily at 5 mg/kg for 6 consecutive weeks to four healthy adult males. No toxicity was observed and again, WBC were significantly elevated (P < 0.05) after supplement. Repair of DNA single strand breaks (SSB) and double strand breaks (DSB) 3 h after 12 Gy whole body irradiation of rats were also significantly improved in C-MED-100 treated animals (P < 0.05). The LD50 and MTD of a single oral dose of C-MED-100 in the rat were observed to be greater than 8 g/kg. Although the rats were treated daily with U. tomentosa extracts at the doses of 10-80 mg/kg for 8 weeks or 160 mg/kg for 4 weeks, no acute or chronic toxicity signs were observed symptomatically. In addition, no body weight, food consumption, organ weight and kidney, liver, spleen, and heart pathological changes were found to be associated with C-MED-100 treatment.
PMID10687868 [PubMed - indexed for MEDLINE]

9. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
Sheng Y, Pero RW, Wagner H.
Department of Cell and Molecular Biology, University of Lund, Sweden. Yezhou.Sheng@wblab.lu.se
Phytomedicine. 2000 Apr;7(2):137-43.
The Uncaria tomentosa water extracts (C-Med-100) depleted of indole alkaloids (< 0.05%, w/w) have been shown to induce apoptosis and inhibit proliferation in tumor cells in vitro and to enhance DNA repair, mitogenic response and white blood cells in vivo. In this study, the effect of C-Med-100 in the treatment of chemically induced leukopenia was evaluated in a rat model. W/Fu rats were treated first with doxorubicin (DXR) 2 mg/kg x 3 (i.p. injection at 24 hour-intervals) to induce leukopenia. Twenty-four hours after the last DXR treatment, the rats were daily gavaged with C-Med-100 for 16 consecutive days. As a positive control, Neupogen, a granulocyte colony stimulator was also administered by subcutaneous injection at a dose of 5 and 10 microg/ml for 10 consecutive days. The results showed that both C-Med-100 and Neupogen treatment groups recovered significantly sooner (p < 0.05 by Duncan test) than DXR group. However, the recovery by C-Med-100 treatment was a more natural process than Neupogen because all fractions of white blood cells were proportionally increased while Neupogen mainly elevated the neutrophil cells. These results were also confirmed by microscopic examination of the blood smears. The mechanism of the C-Med-100 effect on WBC is not known but other data showing enhanced effects on DNA repair and immune cell proliferative response support a general immune enhancement.
PMID10839217 [PubMed - indexed for MEDLINE]

10. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100.
Lamm S, Sheng Y, Pero RW.
Department of Cell and Molecular Biology, Section of Tumor and Immune Biology, University of Lund, Sweden.
Phytomedicine. 2001 Jul;8(4):267-74
A human intervention study was carri ed out using male volunteers attending a General Practice Clinic in New York City involving comparison of individuals supplemented with 350 mg x 2 C-Med-100 daily dose for two months with untreated controls for their abilities to respond to a 23 valent pneumococcal vaccine. C-Med-100 is a novel nutraceutical extract from the South American plant Uncaria tomentosa or Cats Claw which is known to possess immune enhancing and antiinflammatory properties in animals. There were no toxic side effects observed as judged by medical examination, clinical chemistry and blood cell analysis. However, statistically significant immune enhancement for the individuals on C-Med-100 supplement was observed by (i) an elevation in the lymphocyte/neutrophil ratios of peripheral blood and (ii) a reduced decay in the 12 serotype antibody titer responses to pneumococcal vaccination at 5 months.
Publication TypesClinical Trial Randomized Controlled Trial
PMID11515716 [PubMed - indexed for MEDLINE]

11. In vitro Effects of Two Extracts and Two Pure Alkaloid Preparations of Uncaria tomentosa on Peripheral Blood Mononuclear Cells.
Winkler C, Wirleitner B, Schroecksnadel K, Schennach H, Mur E, Fuchs D.
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria.
Planta Med. 2004 Mar;70(3):205-10.
In the traditional Peruvian medicine, hot aqueous extracts of Uncaria tomentosa have been used for the treatment of a wide range of health problems, particularly digestive complaints and arthritis. Some of the beneficial effects observed in patients suggest an immunomodulatory capacity of Uncaria tomentosa extracts. In this study, the effects of two extracts and two mixtures of tetracyclic and pentacyclic oxindole alkaloids of Uncaria tomentosa were investigated in freshly isolated human peripheral blood mononuclear cells (PBMC) stimulated with the mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A) in vitro. Neopterin production and tryptophan degradation were monitored in culture supernatants to determine the effects of the test substances on immunobiochemical pathways induced by interferon-gamma. Compared to unstimulated cells PHA and Con A increased the production of neopterin and degradation of tryptophan (p < 0.01). HCl and ethanol extracts and mixtures of alkaloids of Uncaria tomentosa inhibited both effects in a dose-dependent manner, the lowest effective concentrations of the extracts were 500 - 1000 microg/mL and of the alkaloid mixtures 100 - 175 microg/mL (p < 0.05 and < 0.01). With the highest concentrations of extracts and mixtures complete suppression of mitogen-induced neopterin production and tryptophan degradation was observed. These data demonstrate that Uncaria tomentosa extracts and mixtures of alkaloids modulate the immunobiochemical pathways induced by interferon-gamma. The findings imply a potential application of the extracts as immunoregulators and would be in line with observations in patients using these extracts. Abbreviations. Con A:concanavalin A EDTA:ethylenediaminetetraacetic acid, Titriplex III IDO:indoleamine (2,3)-dioxygenase IFN-gamma:interferon-gamma kyn:kynurenine MTT:3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide PBMC:peripheral blood mononuclear cells PHA:phytohaemagglutinin POA:pentacyclic oxindole alkaloids ROS:reactive oxygen species TOA:tetracyclic oxindole alkaloids trp:tryptophan
PMID15114496 [PubMed - in process]

DisclaimerStatements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Information on this publication should not be used as medical advice. Data prvided for research and professional use only.

Additional Information

Manufacturer Amazon Therapeutic Labs
SKU HA-UNADEGATOLB
Product Type Cut & Sifted Herbs
Volume 1lb.

Amazon Therapeutic Labs

The HERBS AMERICA COMPANY and MACA MAGIC were founded by Jerome River Black. He was the first to cultivate and distribute live maca root plants in the USA and began germplasm collections and cultivar selection of maca in the Peruvian Altiplano in 1994. In addition to his studies of maca in the Peruvian highlands, Jerome is a published ethnobotanist with a myriad of expertise and an extensive history of working within a variety of botanical experiences. He has explored remote rivers, lakes, and forests in dozens of exotic countries, his travels having taken him to the depths of steamy jungles and the tops of 20 thousand foot mountains...

He is the award winner of the Natural Foods Institute "Best New Plants" Award and the subject of numerous articles about plant exploration. He regularly lectures and teaches others about new and rare foodcrop development. Jerry currently resides with his family in the lovely rural area of Murphy, Oregon, surrounded by acres of land containing thousands of varrieties of rare plants from around the world.

Over the course of nearly 20 years, HERBS AMERICA'S founders have used USDA agriculture and agro forestry permits to develop more than 400 rare fruits and new superfoods for introduction into the farming sector and natural foods market. To accomplish this HERBS AMERICA works directly with botanists, tribal leaders, universities, and laboratories to cultivate and research traditional medicines which are found to be beneficial for both humans and the land. Our goal is to bring equitability to small farming operations in developing countries and support indigenous populations in their efforts of preserving culture and environment while at the same time supporting agrarian economies. Working in more than thirty countries around the world, the company donates and exports fruit trees and vegetable seeds to dozens of farmers in countries on several continents.

Our long term philosopy commits us to our product lines long after they leave the farms and jungles. We like to say: "Eat well! Think well! Live close to nature and work for the good of the community!" We believe that traditional wisdom and modern science can combine important resources for a long term vision of biological health. We are adamant in our support of indigenous land rights and sustainable agriculture. A portion of our company's annual budget is designated to help protect natural heritage through conservation projects.

Herbs America Company/ ATL
P.O. Box 411, Murphy, Oregon 
USA - 97533
Tel. +1 541-846-6222
Fax: +1 541-846-9488
http://www.amazonmedicine.com

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